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Ebola survivors donate plasma to tackle outbreak

EUREKALERT                                                                           April 22, 2015
UNIVERSITY OF LIVERPOOL -- 
The first donations of plasma, from survivors of the Ebola epidemic in Sierra Leone, have been received by an international research team working to help tackle current and future disease outbreaks in West Africa.

The team, led by scientists at the University of Liverpool and colleagues at the College of Medicine and Allied Health Services, Ministry of Health, Sierra Leone, is investigating how plasma from Ebola survivors could help treat patients with the disease at the Ebola Treatment Unit, run by the 34th Regiment Military Hospital group in Freetown.

Dr Calum Semple, from the University's Institute of Child Health, and his collaborators developed a convalescent plasma protocol in readiness for an outbreak, such as Ebola, as part of the outbreak preparatory work of the International Severe Acute Respiratory and Emerging Infection Consortium.

The study is one of several being supported by the Wellcome Trust's platform for evaluating experimental Ebola therapeutics in West Africa.

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http://www.eurekalert.org/pub_releases/2015-04/uol-esd042215.php

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Scientists to share real-time genetic data on deadly MERS, Ebola

REUTERS by Kate Kelland                     April 21, 2015

LONDON, April 21 - Genetic sequence data on two of the deadliest yet most poorly understood viruses are to be made available to researchers worldwide in real time as scientists seek to speed up understanding of Ebola and MERS infections.

The project, led by British scientists with West African and Saudi Arabian collaboration, hopes to encourage laboratories around the world to use the live data -- updated as new cases emerge -- to find new ways to diagnose and treat the killer diseases, and ideally, ultimately, prevent them.

"The collective expertise of the world's infectious disease experts is more powerful than any single lab, and the best way of tapping into this...is to make data freely available as soon as possible," said Jeremy Farrar, director of the Wellcome Trust global health charity which is funding the work.

The gene sequences, already available for MERS cases and soon to come in the case of Ebola, will be posted on the website virological.org for anyone to see, access and use.

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http://af.reuters.com/article/topNews/idAFKBN0NC19W20150421?sp=true

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Ebola Analysis Finds Virus Hasn't Become Deadlier, Yet

ICT  INFECTION CONTROL TODAY                                                                  April 14, 2015
(Scroll down for full study)
Research from the University of Manchester using cutting-edge computer analysis reveals that despite mutating, Ebola hasn’t evolved to become deadlier since the first outbreak 40 years ago. The surprising results demonstrate that while a high number of genetic changes have been recorded in the virus, it hasn’t changed at a functional level to become more or less virulent.

The findings, published in the journal Virology, demonstrate that the much higher death toll during the current outbreak, with the figure at nearly 10,500, isn’t due to mutations/evolution making the virus more deadly or more virulent.

As professor Simon Lovell from the Faculty of Life Sciences explains.... What we found was that whilst Ebola is mutating, it isn’t evolving to the point of adapting to become more or less virulent. The function of the virus has remained the same over the past four decades which really surprised us. Unfortunately this does mean the Ebola virus that has now emerged on several occasions since the 1970s will very probably do so again.”

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Ebola rapid diagnostic kit developed by UK scientists in Sierra Leone

Doctors says the kit, if approved by health authorities, could transform the admissions process with its capacity to deliver results within 20 minutes

THE GUARDIAN    by Lisa O'Carroll                              March 29, 2015

A rapid Ebola diagnostic kit similar to a pregnancy kit has been developed by British military scientists and NHS medics in Sierra Leone.

Health care workers prepare to entering a high risk zone at an Ebola virus clinic in Sierra Leone, where the diagnostic kit has been undergoing tests. Photograph: Michael Duff/AP

It can be administered at the bedside and return its first results within 20 minutes, slashing dramatically the normal 24-hour turnaround for lab results.

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British medic declared free of Ebola

BBC  by 

A UK female military medic who has been discharged from hospital after being declared free of Ebola said it was thanks to medics that she is alive.

Anna Cross was the first person in the world to be given the experimental Ebola drug MIL 77, her doctors said.

Corporal Cross, aged 25 from Cambridge, caught the virus while working as a volunteer nurse in Sierra Leone.

Doctors at the hospital...described the drug she was given as a close relative of the medicine ZMapp and that MIL 77 was made in China...

It is too soon to know what role the drug played in Cpl Cross' recovery, they added.

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http://www.bbc.com/news/health-32088310

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Ebola pioneer, stem cell researcher honoured with Canada Gairdner Awards

CANADIAN PRESS                                                                                March 25, 2015
One of the co-discoverers of the Ebola virus and a leading Canadian stem cell researcher are among this year's winners of the prestigious Canada Gairdner Awards.

Dr. Peter Piot is the recipient of the Canada Gairdner Global Health Award, recognizing his work on the discovery of the Ebola virus in 1976 and his leadership in the global response to the HIV-AIDS epidemic.

Dr. Janet Rossant, chief of research at Toronto's Hospital for Sick Children, is the recipient of the 2015 Canada Gairdner Wightman Award, which honours a Canadian who has demonstrated outstanding leadership in medicine and medical science.

Five international scientists are also being honoured with Canada Gairdner Awards, two each from the United States and Japan and one from Switzerland....

Dr. Peter Piot won the 2015 Canada Gairdner Global Health Award in recognition of his work on the discovery of the Ebola virus in 1976 and his leadership in the global response to the HIV-AIDS epidemic. (David Azia/Associated Press)

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How to stop the next epidemic

THE ECONOMIST                                                                                    May 19, 2015

..when the next epidemic breaks out, how do we prevent it from spreading around the world? It is easier said than done.
 
First: Early detection is critical, and it relies on good surveillance. But only 64 of the 194 member states of the World Health Organisation (WHO) have the surveillance procedures, laboratories and data-management capabilities required by the International Health Regulations. Improvements in things like basic public health infrastructure are needed...

Second: A swift response to an outbreak – which might involve getting skilled people, equipment and money to the right places – can potentially save more lives than drugs and vaccines. ... The World Health Organisation and the global community were slow to recognise that there was an international public health emergency.

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Ebola-proof tablet designed by Google rolled out in Sierra Leone disease centre

THE TELEGRAPH by Aislinn Laing                                                                         March 20, 2015

An Ebola-proof tablet that can survive being doused in chlorine and can be used while wearing gloves has been developed by Google and technology volunteers for use by health workers in Sierra Leone.

 

MSFStaff testing one of the Clinical Management Tablets at the Magburaka treatment centre in Sierra Leone Photo: MSF

The Android device, based in a waterproof Sony Xperia with an extra protective casing, allows medics to safely record and share patient temperatures and symptoms over days and weeks....

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FDA panel to discuss Ebola vaccine development in May

REUTERS                                                    March 18, 2015

WASHINGTON ==The U.S. Food and Drug Administration said an advisory panel will discuss the development of Ebola vaccines, days after an American health worker was flown back after being tested positive for Ebola in Sierra Leone.

The federal health regulator would discuss the development of vaccines on May 12, it announced on its website on Wednesday.

The resurgence of the virus last year prompted drugmakers from across the world to develop new treatments that are in different stages of studies....

The World Health Organization said it will decide on mass vaccination against the virus in August.

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http://www.reuters.com/article/2015/03/18/us-health-ebola-fda-idUSKBN0ME1D520150318
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See Federal Register notice of meeting.

https://www.federalregister.gov/articles/2015/03/17/2015-06116/vaccines-and-related-biological-products-advisory-committee-notice-of-meeting

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Ebola vaccine trial to combine GSK, Emergent Bio shots

REUTERS                                                                                                          March 16, 2015

LONDON  - Scientists are to test a new two-shot Ebola vaccine using an experimental shot from Britain's GlaxoSmithKline, which is already in clinical trials in Africa, and a new kind of booster from Emergent BioSolutions.

A health worker, left, injects a man in his arm with an Ebola vaccine in Conakry, Guinea, March 7, 2015. The World Health Organization is starting large-scale testing of an experimental Ebola vaccine in Guinea  to see how effective it might be in preventing future outbreaks of the deadly virus.  (AP Photo/ Youssouf Bah)

The Maryland-based biotech company said on Monday its modified vaccinia Ankara (MVA) Ebola Zaire vaccine would be used in an initial Phase I clinical study to be conducted by researchers at the University of Oxford.

Although Ebola case numbers have fallen to a low level, drug companies are still pushing ahead with efforts to develop an effective vaccine, which may help fight the next outbreak, even if it does not come in time for the current epidemic.

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