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ZMapp - Information Sheet

                                                        

ZMapp TM is the result of a collaboration between Mapp Biopharmaceutical Inc. and LeafBio (San Diego, CA), Defyrus Inc. (Toronto, Canada), the U.S. government and the Public Health Agency of Canada (PHAC).

ZMapp TM is composed of three “humanized” monoclonal antibodies manufactured in plants, specifically Nicotiana.  It is an optimized cocktail combining the best components of MB-­‐003 (Mapp) and ZMAb (Defyrus/PHAC).

ZMapp TM was first identified as a drug candidate in January 2014 and has not yet been evaluated for safety in humans.  As such very little of the drug is currently available.  

Any decision to use an experimental drug in a patient would be a decision made by the treating physician under the regulatory guidelines of the FDA.

Mapp and its partners are cooperating with appropriate government agencies to increase production as quickly as possible.

CLICK HERE - ZMapp - Information Sheet (1 page .PDF file)

http://www.mappbio.com/

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Experimental Ebola Serum Grown in Tobacco Leaves

                                                     

webmd.com - by Brenda Goodman - reviewed by Michael W. Smith, MD

Aug. 4, 2014 -- ZMapp, the experimental treatment rushed to two Americans infected with Ebola in Africa, is grown in specially modified leaves of tobacco -- a plant better known for harming health than healing.

“We complied with a request from Emory University and Samaritan’s Purse to provide a very limited amount of ZMapp last week,” says David Howard, a spokesman for Reynolds American Services, the parent company of Kentucky BioProcessing. The small biopharma company in Owensboro, KY, has been contracted to grow the drug.

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Q & A - What You Need to Know About the Ebola Outbreak

Where is the Outbreak?

      

Source: United Nations Office for the Coordination of Humanitarian Affairs

nytimes.com - by Joe Burgess, Denise Grady, Josh Keller, Heather Murphy and Sergio Peçanha - August 6, 2014

What are the chances of getting Ebola in the United States?

Two American aid workers infected with the Ebola virus while working in West Africa are being treated at a hospital in Atlanta, in a containment unit for patients with dangerous infectious diseases. But the risk that anyone will contract Ebola in the United States is extremely small, experts say.

Doctors across the country are being reminded to ask for the travel history of anybody who comes in with a fever.

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9 Questions About this New Ebola Drug

      

cnn.com - by By Jacque Wilson and Danielle Dellorto - August 5, 2014

(CNN) -- Two American missionary workers infected with the deadly Ebola virus were given an experimental drug that seems to have saved their lives.

Dr. Kent Brantly was given the medication, ZMapp, shortly after telling his doctors he thought he would die, according to a source familiar with his case. Within an hour, doctors say his symptoms -- labored breathing and a widespread rash -- dramatically improved. Nancy Writebol, another missionary working with Samaritan's Purse, received two doses of the medication and has also shown significant improvement, sources say.

As there is no proven treatment and no vaccine for Ebola, this experimental drug is raising lots of questions.

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Ebola - Information, FAQs and Research

An expanding list of information resources on Ebola Virus Disease (EVD).  A link to additional information and a timeline of related events for this outbreak will be provided (in red - here), and at the bottom of this post . . .  . . .

Office of Inspector General - Lead Inspector General Joint Strategic Oversight Plan on U.S. Government Activities: International Ebola Response and Preparedness
http://westafrica.mphise.resiliencesystem.org/lead-inspector-general-joint-strategic-oversight-plan-us-government-activities-international-ebola

Global Communities ALERT Weekly Reports
http://resiliencesystem.org/global-communities-alert-weekly-reports

US - HHS - Ebola Outbreak 2014: Information Resources
http://sis.nlm.nih.gov/dimrc/ebola_2014.html

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CDC - Quarantine Station Contact List, Map, and Fact Sheets

      

cdc.gov - http://www.cdc.gov/quarantine/quarantinestationcontactlistfull.html

Twenty U.S. Quarantine Stations, located at ports of entry and land border crossings, use these public health practices as part of a comprehensive Quarantine System that serves to limit the introduction of infectious diseases into the United States and to prevent their spread.

(CLICK HERE FOR ADDITIONAL INFORMATION)

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Quarantine Stations Set Up at US Airports

      

At LAX and other U.S. airports, CDC quarantine officers are on alert, looking for infected passengers.

abc7.com - by Robert Holguin - August 1, 2014

At Los Angeles International Airport and other U.S. airports, CDC quarantine officers are on alert, looking for infected passengers. . .

. . . The CDC operates quarantine stations at airports across the U.S., including at Los Angeles International Airport, to respond to reports of illness or death.

Officers are trained to spot symptoms of Ebola, and anyone who departs from a flight from an affected country and appears to have symptoms would be tested. If they test positive, they would be rushed to a hospital and quarantined.

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Possible Evacuation of Americans Infected with Ebola Triggers Fears in U.S.

      

The Centers for Disease Control and Prevention outfitted a Gulfstream jet with an isolation pod designed and built by the U.S. Defense Department, the CDC and a private company. The pod, officially called an Aeromedical Biological Containment System, is a portable, tentlike device that ensures the flight crew and others on the flight remain safe from an infectious disease.

kfor.com - by Laura Noland - August 1, 2014

ATLANTA (CNN) — When a plane took off from Georgia to meet two American missionaries fighting to survive Ebola hemorrhagic fever in West Africa, a small epidemic ignited on social media in the United States: Fear.

The medical charter flight that departed Cartersville on Thursday could bring Nancy Writebol or Dr. Kent Brantly back to a treatment facility up the street from the Centers for Disease Control and Prevention in Atlanta. . .

. . . If the plane returns with them lying in the microbial containment system erected in its bay, it will be the first known time that someone infected with Ebola has crossed into the United States.

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