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Leaked documents reveal behind-the-scenes Ebola vaccine issues

SCIENCE INSIDER

By Jon Cohen and  Kai Kupferschmidt                          OCT.23, 2014

Extensive background documents from a meeting that took place today at the World Health Organization (WHO) have provided new details about exactly what it will take to test, produce, and bankroll Ebola vaccines, which could be a potential game changer in the epidemic.

ScienceInsider obtained materials that vaccinemakers, governments, and WHO provided to the 100 or so participants at a meeting on “access and financing” of Ebola vaccines. The documents put hard numbers on what until now have been somewhat fuzzy academic discussions. And they make clear to the attendees—who include representatives from governments, industry, philanthropies, and nongovernmental organizations—that although testing and production are moving forward at record speed, knotty issues remain. 

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http://news.sciencemag.org/health/2014/10/leaked-documents-reveal-behind-scenes-ebola-vaccine-issues

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WHO says Ebola vaccine plans accelerating as trials advance

WHO ANNOUNCES  EBOLA VACCINE TRIALS WILL BE SPEEDED UP TO DECEMBER.
THREE RELATED STORIES.   (Scroll down)

REUTERS                                       OCT. 24

By Stephanie Nebehay and Kate Kelland

GENEVA/LONDON, Oct 24 (Reuters) - Trials of Ebola vaccines could begin in West Africa in December, a month earlier than expected, and hundreds of thousands of doses should be available for use by the middle of next year, the World Health Organization said on Friday.

Vaccines are being developed and made ready in record time by drugmakers working with regulators, the U.N. health agency said, but questions remain about their safety and efficacy which can only be settled by full clinical trials.

"Vaccine is not a magic bullet, but when ready they may be a good part of the effort to turn the tide against the epidemic," senior WHO official Marie-Paule Kieny told a news briefing after a meeting in Geneva of industry executives, global health experts, drug regulators and funders.

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UK pledges £80m more aid to tackle Ebola epidemic in Sierra Leone

 

UPDATE:   EUROPEAN UNION ANNOUNCES ADDITIONAL FUNDING, NAMES AN EBOLA COORDINATOR 

NEW YORK TIMES   

By James Kanter and Andrew Higgins                                                                      OCT. 24, 2014

BRUSSELS--

...  Angela Merkel, the German chancellor, announced tody that Christos Stylianides, the coming European commissioner for humanitarian aid and crisis management, would be named Ebola coordinator.

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Microsoft co-founder Allen to give $100M to fight Ebola

USA TODAY                                                                                               Oct. 23, 014
Bt Brett Melino

Microsoft co-founder Paul Allen says he will pledge at least $100 million to help fight the spread of Ebola.

In a statement released through his personal website on Thursday, Allen says the funding will go to the State Department to develop medevac containment units to evacuate health professionals from West Africa.

Allen is also working with the University of Massachusetts Medical School to donate funds to offer training, medical workers and equipment in Liberia, one of the nations hardest hit by the Ebola epidemic....

Allen is not the first prominent tech name to lend their fortunes toward the Ebola crisis. Last week, Facebook CEO Mark Zuckerberg and his wife, Priscilla Chan, gave $25 million to the CDC Foundation. Last month, fellow Microsoft co-founder Bill Gates donated $50 million through his foundation to battle Ebola.

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Some U.S. hospitals weigh withholding care to Ebola patients

(Reuters) - The Ebola crisis is forcing the American healthcare system to consider the previously unthinkable: withholding some medical interventions because they are too dangerous to doctors and nurses and unlikely to help a patient.

U.S. hospitals have over the years come under criticism for undertaking measures that prolong dying rather than improve patients' quality of life.

But the care of the first Ebola patient diagnosed in the United States, who received dialysis and intubation and infected two nurses caring for him, is spurring hospitals and medical associations to develop the first guidelines for what can reasonably be done and what should be withheld.

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http://www.reuters.com/article/2014/10/22/us-health-ebola-usa-interventions-idUSKCN0IB2OM20141022

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Ebola Guidelines for Doctors’ Offices Are Called Vague and Vary by Region

NEW YORK TIMES                              Oct. 23, 2014

By

....While federal officials have been preoccupied with revamping hospital protocols for handling Ebola patients, critics say guidelines for doctors’ offices, walk-in clinics, blood-testing centers and other outpatient settings have remained spotty and vague.

That has often left local officials and medical associations to fill in the gaps and develop their own policies.

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U.S. tightens Ebola monitoring for West African visitors

NEW YORK -- U.S. health officials imposed fresh constraints on Wednesday on people entering the country from three countries at the center of West Africa's Ebola epidemic, mandating that they report their temperature daily and stay in touch with health authorities.

U.S. Coast Guard Health Technician Nathan Wallenmeyer (L) and Customs Border Protection (CBP) Supervisor Sam Ko conduct prescreening measures on a passenger arriving from Sierra Leone at O’Hare International Airport's Terminal 5 in Chicago, in this handout picture taken October 16, 2014.

The move announced by the U.S. Centers for Disease Control and Prevention (CDC) marked the latest precautions put in place by the U.S. government to stop the spread of the virus, but stopped short of a ban on travelers from Liberia, Sierra Leone and Guinea as demanded by some lawmakers.

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EBOLA RESPONSE ROAD MAP SITUATION REPORT

 

                                                                            22, October, 2014

WHO's  new report says the number of confirmed,suspected and probable Ebola cases has reached 9936 with 4877 deaths confirmed.

See full Report and graphs

http://apps.who.int/iris/bitstream/10665/137091/1/roadmapsitrep22Oct2014_eng.pdf?ua=1

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Ebola Outbreak Erodes Recent Advances in West Africa

NEW YORK TIMES                                 Oct. 22, 2014

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21-day quarantine for Ebola may not be enough to prevent spread of virus: Study

HOMELAND SECURITY NEWS WIRE                                              Oct. 20, 2014

As medical personnel and public health officials are responding to the first reported cases of Ebola Virus in the United States, many of the safety and treatment procedures for treating the virus and preventing its spread are being reexamined. One of the tenets for minimizing the risk of spreading the disease has been a 21-day quarantine period for individuals who might have been exposed to the virus.

 A new study by Charles Haas, Ph.D., a professor in Drexel’s College of Engineering, suggests, however, that twenty-one days might not be enough completely to prevent spread of the virus.

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http://www.homelandsecuritynewswire.com/dr20141020-21day-quarantine-for-ebola-may-not-be-enough-to-prevent-spread-of-virus-study

Link to the study
http://currents.plos.org/outbreaks/article/on-the-quarantine-period-for-ebola-virus/

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