Research

MEDICALXPRESS                                                                                                 March 9, 2015
Researchers from Emory and the Centers for Disease Control and Prevention have now obtained a first look at the immune responses in four Ebola virus disease survivors who received care at Emory University Hospital in 2014, by closely examining their T cells and B cells during the acute phase of the disease. The findings reveal surprisingly high levels of immune activation, and have implications for the current effort to develop vaccines against Ebola.

The Ebola virus, isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells in a BSL-4 suite at Rocky Mountain Laboratories. Credit: NIAID

REUTERS by Kate Kelland and Tom Miles                      March 5, 2015

LONDON/GENEVA --Final stage trials of an Ebola vaccine being developed by Merck and NewLink Genetics will begin in Guinea on March 7, the World Health Organization said on Thursday.

Signaling global health authorities' determination to see through trials despite a sharp drop in cases in the West Africa epidemic, the WHO said a second shot, developed by GlaxoSmithKline will be tested "in a sequential study, as supply becomes available".

All three worst-hit countries - Guinea, Liberia and Sierra Leone - aim to conduct final-stage trials of vaccines, and Liberia is already testing the GlaxoSmithKline and Merck-NewLink shots, while Sierra Leone is expected to announce plans soon.

But recent steep declines in new Ebola cases will make it far harder to prove whether experimental vaccines work, as the vaccine's effect will be difficult to establish.

The WHO, however, said it was committed to pushing ahead.

Read complete story.
http://www.reuters.com/article/2015/03/05/us-health-ebola-vaccine-idUSKBN0M10ZD20150305

REUTERS by Stephanie Nebehay                                                             Feb. 27, 2015

GENEVA -- An independent advisory body will decide in August at the earliest on whether to recommend widespread introduction of an Ebola vaccine, depending on results of clinical trials and the epidemic's course, the World Health Organization said on Friday.

All three worst-hit countries in West Africa - Guinea, Liberia and Sierra Leone - aim to conduct phase III final-stage clinical trials of experimental vaccines.

Liberia is already testing both the GlaxoSmithKline and Merck-NewLink vaccines, while Sierra Leone and Guinea are due to announce plans soon....

WHO spokesman Christian Lindmeier, reporting on a three-day meeting of experts, told a news briefing: "Vaccine introduction is by no means a given and will depend on the results of clinical trials and recommendations from WHO's Strategy Advisory Group of Experts (SAGE) on vaccines and immunization....

Read complete story.

AFP                                                                                                                    Feb. 17, 2015

London--  A team of leading international scientists on Tuesday called for new Ebola vaccines to be made available in months rather than years and warned against complacency after a reduction in infection rates.

(Scroll down for link to complete report.)

"Despite falling infection rates in west Africa, the risk that the current Ebola outbreak may not be brought completely under control remains," said Jeremy Farrar, director of the Wellcome Trust, Britain's biggest medical charity.

"The accelerated development of candidate vaccines... is essential," said Farrar, who co-chairs a group of 26 international experts on vaccine development.

Read complete story.

http://news.yahoo.com/scientists-warn-against-complacency-ebola-vaccines-004937305.html;_ylt=AwrBEiHDVuNUhDcAfsPQtDMD

Recommendations for Accelerating the Development of Ebola Vaccines: Report & Analysis