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New CRISPR Tool Can Detect Tiny Amounts of Viruses

The Cas13a enzyme causes collateral RNA damage that is the heart of a new diagnostic system, SHERLOCK, that can detect minute quantities of virus and much more.  Broad Institute

CLICK HERE - Nucleic acid detection with CRISPR-Cas13a/C2c2

sciencemag.org - by Jon Cohen - April 13, 2017

 . . . That’s the realm of SHERLOCK, a new diagnostic system that can detect attomolar levels of viruses in a sample and also distinguish Zika from its close relative, dengue. This exquisitely sensitive and specific tool promises to help detect diseases that other diagnostics miss, and it’s simple and cheap to use. Sexier still, it exploits a variation of CRISPR, the genome-editing method that has become the rage in biology.

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ALSO SEE RELATED STUDIES WITHIN THE LINKS BELOW . . .

CLICK HERE - Nature - Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

CLICK HERE - Cell - Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components

 

 

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