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Ebola crisis update MSF

 

MSF                                                  July 17, 2015

Though Ebola has faded from the news headlines, the epidemic in West Africa continues to claim lives today. Around 30 people become infected each week in Sierra Leone and Guinea – a number that would be considered a major disaster under normal circumstances – and the outbreak has recently re-emerged in Liberia.

  • Liberia: After being declared Ebola-free on 9May, six (6) new cases have been confirmed since the re-emergence of the virus at the end of June.
  • Guinea: 13 confirmed cases in the country in the week to 12July in three main hotspots (Forecariah, Boké/Fria, Conakry)
  • Sierra Leone: 14 confirmed cases in the country in the week to 12July in three main hotspots (Freetown, Port Loko, Kambia).  

Read complete report:

http://www.msf.org/article/ebola-crisis-update-17-july-2015

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Guinea's president on global aid push: 'Ebola forced us to change completely'

After the international community pledged $3.4bn for West Africa, Alpha Condé is cautiously optimistic and taking stock of lessons learned

Guinean president Alpha Conde speaks to UN members during an International Ebola Recovery Conference on 10 July. Photograph: EDUARDO MUNOZ ALVAREZ/AFP/Getty Images

THE GUARDIAN by Raya Jababi                        June 11, 2015
NEW YORK--More than a year after the charity Médecins Sans Frontières sounded the alarm on the Ebolaepidemic that would claim more than 11,000 lives, the international community on Friday pledged $3.4bn to help affected West African countries recover.

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Finger-prick, blood test for Ebola takes just minutes

THE WASHINGTON POST by

Public health officials may soon be able to screen patients for Ebola at border crossings and hospitals with a finger-prick blood test that takes mere minutes.

The development of the rapid diagnostic test, reported in The Lancet Thursday, represents a significant victory for scientists around the world who have been experimenting over the past year with all manner of vaccines, treatments and other ways of eradicating the virus.

Developing a way of confirming Ebola in a patient has been one of the top priorities. In the early stages the symptoms -- chest pain, cough, nausea -- can look like many other illnesses, making it very difficult for doctors to triage -- to determine who should be quarantined and who to send home. It can often take days or longer for laboratory tests, the current standard, to return a positive or negative result.

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Neglected Tropical Diseases in the Ebola- Affected Countries of West Africa

PLOS   EDITORIAL by Peter J. Hotez, Sabin Vaccine Institute                          June 25, 2015
While global attention in West Africa is focused on the emergence of Ebola virus infection, new information from the published literature and World Health Organization databases reveals that many other neglected tropical diseases (NTDs) are far more widespread and also require urgent attention.
Well before Ebola virus infection emerged in West Africa at the end of 2013, the three
major affected countries--Guinea, Liberia, and Sierra Leone were already known to
be highly affected by NTDs....
Today, new information from the recent literature and the World Health Organization
(WHO) Preventive Chemotherapy and Transmission (PCT) Control databases reveals that
NTDs remain widespread in Guinea, Liberia, and Sierra Leone.  An estimated
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Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis

LANCET by Patrick G. T. Walker and others                               Volume 15, No. 7, p825–832, July 2015
The ongoing Ebola epidemic in parts of west Africa largely overwhelmed health-care systems in 2014, making adequate care for malaria impossible and threatening the gains in malaria control achieved over the past decade. We quantified this additional indirect burden of Ebola virus disease.

We estimated the number of cases and deaths from malaria in Guinea, Liberia, and Sierra Leone from Demographic and Health Surveys data for malaria prevalence and coverage of malaria interventions before the Ebola outbreak. We then removed the effect of treatment and hospital care to estimate additional cases and deaths from malaria caused by reduced health-care capacity and potential disruption of delivery of insecticide-treated bednets. We modelled the potential effect of emergency mass drug administration in affected areas on malaria cases and health-care demand....

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Vaccine trial won’t cause Ebola - WHO

GRAPHIC ONLINE by Rebecca Quisacde-Duho and Rhodaline Oppong                              June 20, 2015

Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong
Rebecca Quaicoe-Duho & Rhodaline Oppong

The World Health Organisation (WHO) has assured Ghanaians that the proposed Ebola vaccine trial will not cause Ebola in the country.

WHO says it views the safety of people as paramount and would, therefore, not overlook any wrongdoing in the development of a vaccine.

 The WHO Country Representative, Dr Magda Robalo, gave the assurance at a public sensitisation forum in Accra last Thursday....

 Recently, following public agitations, the Minister of Health, Mr Alex Segbefia, called for more consultation on the proposed Ebola vaccine trial which was to be undertaken at Hohoe in the Volta Region.

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Ebola showed aid delivery desperately needs an overhaul

REUTERS  by Stella Dawson                                                          JUNE 18, 2015

WASHINGTON -- The Ebola epidemic exposed long-standing holes in aid delivery,  which desperately needs an overhaul before the next international emergency hits, aid experts said on Thursday.

Supplies for the Ebola zone in West Africa wait to be loaded at New York's John F. Kennedy International Airport September 20, 2014. REUTERS/Carlo Allegri

Many of the shortcomings seen during the Haiti earthquake of slow responses and uncoordinated relief efforts were repeated during the Ebola crisis that erupted in West Africa a year ago, they said.

With Sierra Leone and Guinea continuing to report cases of the deadly virus, the international community must act urgently, said Carolyn Reynolds, external relations manager at the World Bank.

"We need to think outside the box," she said at a panel on global health preparedness held on Capitol Hill.

Read complete story.
www.trust.org/item/20150618215202-ilvea/?source=fiOtherNews2

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Ebola genetic code analysed to show evolution of worst ever outbreak

THE GUARDIAN   by Ian Sample                                                                             June 18, 2015

Scientists have analysed the genetic code of Ebola viruses from patients across west Africa and pieced together the evolution of the worst ever outbreak of the killer disease.

Experts from Public Health England at Porton Down in Britain, the World Health Organisation (WHO), and other leading labs, used DNA from 179 Ebola samples to reconstruct the spread of the virus from Guinea into surrounding countries last year.

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Why Some Ebola Strains Are More Dangerous Than Others

CHEMISTRY WORLD by Christopher Barnard             June 17, 215
The virulence of Ebola virus strains appears to be innately linked to the degree of disorder in proteins that form their nucleocapsids. Computational analysis has revealed that strains responsible for the most lethal outbreaks of Ebola show significantly higher levels of intrinsic protein disorder than less virulent strains, in a discovery that could constitute a major breakthrough in understanding the pathogen’s behaviour.

With over 27,000 confirmed, probable and suspected cases and more than 11,000 fatalities worldwide, the ongoing Ebola outbreak has resulted in considerably more casualties since late 2013 than all other outbreaks combined. There are no effective treatments or vaccines against the haemorrhagic fever that evinces Ebola infection; however, strains of the virus with drastically different virulence have emerged since the first outbreak in 1976, with fatality rates ranging from 25 to 90%.

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Ebola vaccines in limbo expose need for more speed in trials

REUTERS by Kate Keller and Ben Hirschler                                      June 17, 2015

LONDON --Drugmakers' plans to conduct vast clinical trials to test and hopefully validate the first Ebola vaccines have been thwarted by success in beating back the deadly epidemic in West Africa.

GlaxoSmithKline, Merck and Johnson & Johnson are struggling to recruit volunteers with enough exposure to the disease to prove whether their vaccines are doing the job and preventing infection.

The story might have been very different with just another three or four months of disease spread, underscoring the need to act more quickly to develop vaccines for emerging diseases....

Guinea, where Ebola is still infecting new victims, as "the only hope" for showing efficacy, according to Kieny and to Adrian Hill, director of the Jenner Institute at Britain's Oxford University.

The WHO is overseeing the so-called ring vaccination study in Guinea in which close contacts and family around each new case of Ebola are vaccinated -- either immediately or after a three-week delay -- to see if the shot offers protection.

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