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The Ebola questions

Scientists know a lot about the virus that causes Ebola — but there are many puzzles that they have yet to solve.

NATURE SCIENCE International Weekly Journal of Science                                   Oct. 29, 2014

By Erika Check Hayden

Scientists know a lot about the virus that causes Ebola — but there are many puzzles that they have yet to solve.

An Ebola virus particle from the 2014 outbreak.

To much of the world, the virus behind the devastating Ebola outbreak in Africa seems to have stormed out of nowhere. But Leslie Lobel thinks we should have seen it coming.

In 2012, Lobel and a team of researchers spent six months in Uganda studying the Ebola virus and related viruses. Over the course of their stay, these pathogens caused at least four separate outbreaks of disease in central Africa, affecting more than 100 people. To Lobel, a virologist at Ben-Gurion University of the Negev in Beer-Sheva, Israel, the outbreaks felt like the small tremors that can precede a major earthquake. “We all said, something is going on here; something big is going to happen,” he says.

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Genes Influence How Mice React to Ebola, Study Says In ‘Significant Advance’

NEW YORK TIMES                        Oct. 30, 2014

By Gina Kolata

Some people exposed to the Ebola virus quickly sicken and die. Others become gravely ill but recover, while still others only react mildly or are thought to be resistant to the virus. Now researchers working with mice have found that these laboratory animals, too, can have a range of responses to Ebola, and that in mice, the responses are determined by differences in genes.

Researchers at the University of Washington have been studying the Ebola virus in mice, and have found that the effects of the virus may be determined by genes.Video and photo by University of Washington.

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Most Ebola Patients in the U.S. Survive. Half in Africa Die. Why Are We Letting This Happen?

THE NEW REPUBLIC                                                                      Oct. 29, 2014
ByJonathan Cohen
.... “An Ebola diagnosis need not be a death sentence,” Paul Farmer, an infectious disease specialist at Harvard, wrote in an influential essay for the London Review of Books. “If patients are promptly diagnosed and receive aggressive supportive care—including fluid resuscitation, electrolyte replacement and blood products—the great majority, as many as 90 percent should survive.”

The survival rate in West Africa has been a lot lower than 90 percent...

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Clinical Illness and Outcomes in Patients with Ebola in Sierra Leone

NEW ENGLAND JOURNAL OF MEDICINE

A study and analayisis of patients in Siere Leone suspected of Ebola infections, tested between May 25 and June 18, 2014
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http://www.nejm.org/doi/full/10.1056/NEJMoa1411680#t=articleTop

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Lack of federal authority makes fashioning coherent national Ebola policy difficult

Discussion of conflicting quarantine guidelines

HOMELAND SECURITY NEWSWIRE                     Oct. 30, 1014
Earlier this week, the Centers for Disease Control and Prevention(CDC) issued new guidelines on how states should deal with travelers from Ebola-stricken regions, but a lack of federal authority to mandate such guidelines has led to conflicting strategies, varying from state to state, which includes mandatory at-home quarantine for some travelers. Under current U.S. law, the states have the authority to issue quarantine or isolation policies, and they also control the enforcement of these policies within their territories.

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http://www.homelandsecuritynewswire.com/dr20141030-lack-of-federal-authority-makes-fashioning-coherent-national-ebola-policy-difficult

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Home> Health Ebola: Danger in Sierra Leone, Progress in Liberia

UPDATE WITH TEXT OF LATEST WHO REPORT

http://apps.who.int/iris/bitstream/10665/137376/1/roadmapsitrep_29Oct2014_eng.pdf

 

ASSOCIATED PRESS                                                                      Oct. 30, 2014
By CLARENCE ROY-MACAULAY and JONATHAN PAYE-LAYLEH

FREETOWN, Sierra Leone --Liberia is making some progress in containing the Ebola outbreak while Sierra Leone is "in a crisis situation which is going to get worse," the top anti-Ebola officials in the two countries said.

The people of both countries must redouble efforts to stop the disease, which has infected more than 13,000 people and killed nearly 5,000, the officials said. Their assessments underscore that Ebola remains a constant threat until the outbreak is wiped out. It can appear to be on the wane, only to re-emerge in the same place or balloon elsewhere if people don't avoid touching Ebola patients or the bodies of those who succumb to the disease.

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No Ebola, S'il Vous Plait, We're French: The Ivory Coast Mindset

NPR                                                  Oct. 29, 2014
By Gregory Warner

There are all kinds of theories why Ebola hasn't arrived in Ivory Coast, despite the fact that it shares a long and very porous border with two Ebola-afflicted countries, Liberia and Guinea....

 

  Mumadou Traore, a field coordinator for CARE International, says the Ivory Coast's French bureaucracy is a "blessing"    when it comes to Ebola.

Dr. Seydou Coulibaly is the regional health director of Tompki county, which shares the longest border with Liberia and Guinea. He says that in the first weeks of the outbreak, before official prevention directives were issued from the capital, he was telling clinics and hospitals to send him daily Ebola watch reports. He gets a hundred a day. Even before the borders were sealed, he was sending health workers to take people's temperature when they crossed. He's also arranged trainings for schoolteachers and soldiers.

All these efforts will help, he says — maybe not to prevent the virus from coming to the country but at least the first eventual case will be well-managed. That's the main objective.

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Rate of new Ebola infections in Liberia is slowing, WHO says

OVERVIEW OF DEVELOPMENTS DURING PAST DAY

WASHINGTON POST                            Oct. 30, 2014
By Lena H. Sun, Brady Dennis and Joel Achenbach
New Ebola infections in virus-ravaged Liberia appear to be declining for the first time in months, the World Health Organization said Wednesday.

Until now, officials have been suspicious of this encouraging trend, thinking it might be an artifact of poor data collection, a symptom of chaos in countries that were overwhelmed by the crisis. But Bruce Aylward, a top WHO official, said Wednesday that the decline in new cases “is real,” measured by scores of empty beds in Ebola clinics, fewer cases confirmed by laboratory tests and a drop in burials by specially trained teams.

Still, the WHO and other officials remain wary because the nature of this outbreak has been one of unpredictable surges and declines.

“It’s like saying your pet tiger is under control,” Aylward said. “This is a very, very dangerous disease.”

Meanwhile President Obama continued to criticize the calls for mandatory quarantines for returning volunteers

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Ebola Virus Disease and the Need for New Personal Protective Equipment

JOURNAL OF AMERICAN MEDICICAL ASSOCIATION      Oct. 28, 2014
Michael B. Edmond, MD, MPH, MPA1; Daniel J. Diekema, MD, MS1; Eli N. Perencevich, MD, MS

"...it is clear that reengineering of personal protecion equipment is required, both in US hospitals but more critically for the outbreak zones in Africa. The use of cumbersome PPE in the extreme heat and difficult working conditions of Ebola treatment centers in Africa places great stress on health care workers and limits the time they can spend providing patient care.

" A novel approach to PPE that provides an impermeable fluid barrier that is both more comfortable and easier to don and remove would be a substantial step forward.

"This will require new materials and designs. Indeed, the US Agency for International Development, White House Office of Science and Technology Policy, CDC, and US Department of Defense have recently announced a campaign to develop and test innovations for PPE in response to the Ebola outbreak."

Read complete article
http://jama.jamanetwork.com/article.aspx?articleid=1920943

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Ebola: California is latest state to impose 21-day quarantine for those exposed to Ebola

SAN JOSE MERCURY NEWS                                                        Oct. 29, 2014

By Julia Prodis Sulek

California on Wednesday became the latest state to order a 21-day quarantine for travelers who have been in close contact with Ebola patients.

In an attempt to avoid the criticism lodged against New York, New Jersey and Maine that had blanket quarantine orders, however, California will allow county health agencies to impose the quarantine on a case-by-case basis.

By working with county health departments to assess the individual risks, the California Department of Public Health said it "respects the individual circumstances of each traveler while protecting and preserving the public health."

Quarantine can range from observation and monitoring to the "limitation on his or her freedom of movement."

In the Bay Area, a Stanford doctor who returned last week from Liberia where he was treating Ebola patients was already being monitored by the San Mateo County Department of Public Health. The department coordinated with the CDC and San Francisco International Airport when Dr. Colin Bucks arrived late last week. He had no symptoms of the disease and came to an agreement with health officials to avoid contact with others but can leave the house for limited activities, such as jogging alone.

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