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Probing Ebola's Deadly Inflammatory Effect

      

New research suggests that Ebola's deadly inflammatory effects may be caused by the result of protein shedding by infected cells. (Victor Volchkov / PLOS Pathogens)

CLICK HERE - RESEARCH - PLOS Pathogens - Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

latimes.com - by Monte Morin - November 20, 2014

New research suggests that the massive and destructive inflammation that characterizes Ebola virus disease may be caused by the release of foreign proteins from infected cells.

Although Ebola is infamous for causing bleeding in some of its victims, doctors say the vast majority of deaths are the result of organ failure and shock brought on by the uncontrolled release of cytokines, compounds that cells use to communicate with one another and control immune response. . .

. . . In a paper published Thursday in Plos Pathogens, researchers at the Claude Bernard University of Lyon, in France, argued that glycoprotein shedding by infected cells may explain the immune system's damaging response.

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Mali records new Ebola case, linked to dead nurse

REUTERS                                                                                                                        Nov. 22, 2014

BAMAKO -- Mali has recorded a new case of Ebola in the capital Bamako after the friend of a nurse who died of the hemorrhagic fever earlier this month tested positive for the disease, health and medical officials said on Saturday.

The nurse contracted the disease after treating an imam from neighboring Guinea, who died after being incorrectly diagnosed with kidney problems. This allowed Ebola to spread to five other people in the West African nation's second outbreak.

"Of two suspected cases tested, one was negative and the other positive. The latter was placed in an isolation center for intensive treatment," a statement from the health ministry said, adding that another 310 contact cases were being monitored.

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http://www.reuters.com/article/2014/11/22/us-health-ebola-mali-idUSKCN0J60EI20141122

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Ebola crisis now 'stable' in Guinea, WHO says

BBC                                                                                                                          Nov. 22, 2014

The Ebola outbreak is now "relatively stable" in Guinea, where the latest crisis began, the World Health Organization says.

There were still some flare ups in the south-east, but things were improving in other prefectures, WHO co-ordinator Dr Guenael Rodier told the BBC....

Ebola patients are taken to dedicated treatment centres across Guinea

"When you look in more detail, you see that it's still quite active in the Guinea forest area [in] the south of the country," Dr Rodier said.

However, he added that the situation was "actually improving in a number of prefectures, especially Conakry", where there was a fairly good understanding of how the disease was spreading.

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http://www.bbc.com/news/world-africa-30160659

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An Ebola Clinic Figures Out A Way To Start Beating The Odds

NATIONAL PUBLIC RADIO                                                                                                        Nov. 21, 2014
by Nurith Aizenman

FREETOWN, Sierra Leone

Description of how the Hastings Ebola Treatment Center in Freetown, Sierra Leone is having success by having experienced nurses useIV's to counter the dehydration of Ebola patients.

Health workers are disinfected with a chlorine solution after treating patients at the Hastings Ebola Treatment Center in Freetown.

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http://www.npr.org/blogs/goatsandsoda/2014/11/21/365715575/an-ebola-clinic-figures-out-a-way-to-start-beating-the-odds

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First British volunteers fly to Sierra Leone to battle Ebola

THE ASSOCIATED PRESS                                Nov. 22, 2014

FREETOWN, Sierra Leone -- The first wave of volunteers from Britain's National Health Service arrived in Sierra Leone Saturday amid what the World Health Organization has described as an "intense" surge in cases.

A sign reading 'Kill Ebola Before Ebola Kill You', on a gate is mounted as part of the country's Ebola awareness campaign in the city of Freetown, Sierra Leone, Sept. 14, 2014. (AP / Michael Duff, File)

More than 30 NHS staffers, including general practitioners and nurses, were expected to stay in Freetown, the capital, for one week of training before moving to treatment centres across the country, Britain's Department for International Development said in a statement.

They join nearly 1,000 British soldiers, scientists and aid workers already in the country participating in the Ebola fight, International Development Secretary Justine Greening said.

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UN security council criticises discrimination against those from Ebola-hit regions

THE GUARDIAN                                                    Nov. 21, 2014
THE UNITED NATIONS --The UN security council has criticized travel bans against nationals from Ebola-hit countries.

Last month the Australian immigration minster, Scott Morrison, announced Australia would stop granting temporary visas to visitors from west Africa. The security council statement criticised such blanket bans and urged countries to maintain links with affected countries.

“The security council expresses its continued concern about the detrimental effect of the isolation of the affected countries as a result of trade and travel restrictions imposed on and to the affected countries as well as acts of discrimination against the nationals of Guinea, Liberia, Mali and Sierra Leone,” said Julia Bishop, the Australian foreign mniister who was presiding over the session Thursday.

The council statement also described the Ebola outbreeak in Africa as "a threat to international peace and security..."

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Officials Revise Goals on Containing Ebola After Signs of Wider Exposure in Mali

NEW YORK TIMES                                     Nov. 21, 2014
By and

The leaders of the United Nations and the World Health Organization expressed renewed alarm on Friday about Ebola’s tenacity in Africa and, in particular, its potential to ravage a fourth country, Mali, where they said hundreds of people had been exposed to an infected cleric who died last month.

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British-built Ebola hospital in Sierra Leone only partly operational

THE GUARDIAN                                                                                                                         Nov. 21, 2014
By Lisa O'Carroll

The Ebola hospital built by the British army which opened two weeks ago in the capital of Sierra Leone will not be fully operational until January, it has emerged.

The facility was the first of six hospitals announced by the Department of International Development two months ago as part of Britain’s £250m assistance in the fight against Ebola in the country....

 

Equipment wrapped in plastic inside the Kerry Town Ebola Treatment Centre in Sierra Leone before it opened. Photograph: Louis Leeson/Save the Children

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Ebola Deaths Near 5,500 As Virus Still Rages

WALL STREET JOURNAL                                                                                               Nov. 21, 2014

By Andrew Morse

ZURICH—Nearly 5,500 people have died from Ebola, the World Health Organization said Friday, adding that the rate of transmission remains intense in the three West African countries at the center of the epidemic.

Medical staff members of the Croix Rouge NGO put on protective suits before collecting the corpse of a victim of Ebola, in Monrovia, Liberia. Agence France-Presse/Getty Images

In an update, the United Nations health agency said 15,351 confirmed, suspected or probable cases of Ebola had been reported in eight countries that have been affected by the disease. Most of the cases were concentrated in Guinea, Liberia and Sierra Leone.

A total of 5,459 people have died of Ebola since the outbreak began, the WHO said. On Wednesday, the WHO reported 15,145 cases and 5,420 deaths.

Ebola’s true overall toll is difficult to gauge because some hard-hit villages are remote and urban centers have showed resistance toward clinics....

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