Situation Report

Dengue-infected tissue - CDC; Frederick Murphy, Cynthia Goldsmith

CLICK HERE - STUDY - Dengue Virus Antibodies Enhance Zika Virus Infection

Previous flavivirus infection could help explain the severity of symptoms in some people infected during the ongoing Zika outbreak, researchers report.

The Scientist - by Tanya Lewis - April 28, 2016

Scientists at Florida Gulf Coast University and their colleagues have found that human cells were more likely to be infected with Zika virus in vitro if they contained antibodies to dengue virus. Their findings, detailed Monday (April 25) in a bioRxiv preprint, could help explain why Zika infection appears to be more severe in areas where dengue is endemic, and points to a potential unintended effect of dengue vaccination.

Antibodies to dengue can increase the virus’s infectivity for certain types of immune cells through a process called antibody-dependent enhancement (ADE), resulting in the production of more virus and more severe illness.

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published by Liz Szabo

6:47 p.m. EDT May 2, 2016

ATLANTA — The need for drugs to prevent and treat Zika infections grows with every new patient diagnosed. The virus causes devastating birth defects and is strongly linked to a type of paralysis called Guillain-Barre syndrome.

There are currently no approved drugs against Zika; developing a new medication for any disease can take 10 to 20 years.

"The sense of urgency is enormous," said Mauro Martins Teixeira, who heads the immunopharmacology laboratory at the Federal University of Minas Gerais in Brazil. "In an emergency, everyone wants quick answers."

Dive Brief:

City’s Zika action plan enhances mosquito surveillance and control - Expands testing of humans and mosquitos, and launches public awareness campaign

nyc.gov - April 18, 2016

NEW YORK––Marking the start of mosquito season, Mayor de Blasio today detailed a three-year, five-borough plan to protect New Yorkers and prevent the spread of the Zika virus in New York City.

“We are doing all we can to target the mosquito that could transmit Zika here in the city, and building the capacity to respond to every possible scenario, no matter how unlikely,” said Mayor Bill de Blasio. “We will spare no effort to protect pregnant New Yorkers from the devastating consequences of Zika, and we ask New Yorkers to help us by taking simple steps to get rid of standing water where mosquitos can breed. We also ask pregnant women who may have been exposed to Zika to talk to their doctors about getting tested.”

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