Sierra Leone

Rhode Island Hospital Physician Comes Up With New Diagnostic Tool for Ebola Virus

news-medical.net - April 6, 2015

Adam C. Levine, M.D., an emergency medicine physician at Rhode Island Hospital and The Miriam Hospital who treated Ebola-infected patients in Liberia last year, used his field experience to create a tool to determine the likelihood that patients presenting with Ebola symptoms will actually carry the virus. His research was published in the Annals of Emergency Medicine today.

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CLICK HERE - RESEARCH - Derivation and Internal Validation of the Ebola Prediction Score for Risk Stratification of Patients With Suspected Ebola Virus Disease

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Sierra Leone to start laying off Ebola workers as cases fall: president

REUTERS  by Umaru Fofana                                                                             April l, 2015

FREETOWN-- Sierra Leone's President Ernest Bai Koroma said on Wednesday authorities would soon start laying off staff recruited to fight Ebola as the numbers of cases decline, but these workers would be employed elsewhere, where possible....

Addressing the country about the outbreak, Koroma said the infection rate was falling "week by week" and the number of treatment facilities and staff would be reduced, despite the need for continued vigilance....

At the peak of the crisis last year, authorities were struggling to recruit local and foreign medics to tackle Ebola, which has killed nearly 500 local health workers in West Africa, according to United Nations statistics.

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http://www.reuters.com/article/2015/04/02/us-health-ebola-leone-idUSKBN0MT01120150402

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Liberia, Sierra Leone gain in Ebola crisis; Guinea struggles

ASSOCIATED PRESS  by Sarah DiLorenzo                                                               April 2, 2015      

(Scroll below for related Wall Street Journal story.)   

DAKAR, Senegal (AP) — When will the world's largest and longest Ebola outbreak end? The West African countries of Sierra Leone and Liberia both appear to be on steady paths to ending the epidemic. The wild card is Guinea, where Ebola hasn't burned as hot but remains stubbornly entrenched.

 

In this file photo dated Friday, March. 27, 2015, a usually busy street is deserted as Sierra Leone enters a three day country wide lockdown on movement of people due to the Ebola virus in the city of Freetown, Sierra Leone. Sierra Leone's 6 million people were told to stay home for three days, except for religious services, beginning Friday as the West African nation attempted a final push to rid itself of Ebola. (AP Photo/ Michael Duff, FILE)

Liberia's last Ebola patient died March 27; it is now counting down the 42 days it must wait to be declared free of Ebola. Meanwhile, Sierra Leone recorded no new infections Wednesday for the second time; on average, it has logged a handful each day in recent days.

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Merck, NewLink Ebola vaccine appears safe, effective in new studies

REUTERS by Sharon Bagley                                                                      April 1, 2015

Early-stage trials of an experimental Ebola vaccine, two in the United States and four in Africa and Europe, have found that it appears to be safe and triggered robust production of Ebola-fighting antibodies, scientists reported on Wednesday.

Since trials cannot ethically expose volunteers to Ebola, the production of antibodies is a proxy for whether vaccines could prevent or even treat the disease.

The trials all tested a vaccine called VSV-ZEBOV, which was developed at the Public Health Agency of Canada and licensed to NewLink Genetics Corp and then to Merck & Co Inc. It consists of a cattle virus called rVSV that has been engineered to carry Ebola genes, which produce proteins meant to trigger production of anti-Ebola antibodies.

According to separate teams of scientists, that is what happened, two papers in the New England Journal of Medicine reported.

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http://www.reuters.com/article/2015/04/01/us-health-ebola-vaccine-idUSKBN0MS5DN20150401

Read NEW ENGLAND JOURNAL OF MEDICINE  papers

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App enables self-reporting of possible Ebola symptoms in Maryland

ASSOCIATED PRESS                                                                                     April 1, 2015

BALTIMORE — A Baltimore company and Maryland public health officials are announcing a smartphone and Web application for self-reporting possible Ebola symptoms.

Emocha Mobile Health Inc. said Wednesday that people returning from affected West African nations can use the app to report their temperature and any symptoms twice daily to the Department of Health and Mental Hygiene. The federal government recommends such reporting for 21 days.

The state health agency has operated a call center since October for monitoring people known to have been in affected countries. The app eventually will link to the state's database of such individuals to automate the reporting of data to Maryland and federal authorities.

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Faulty modeling studies led to overstated predictions of Ebola outbreak

MEDICAL EXPRESS                                                                       MARCH 31, 2015

(scroll down for complete paper.)

Frequently used approaches to understanding and forecasting emerging epidemics—including the West African Ebola outbreak—can lead to big errors that mask their own presence, according to a University of Michigan ecologist and his colleagues.

Last September, the U.S. Centers for Disease Control and Prevention estimated—based on computer modeling—that Liberia and Sierra Leone could see up to 1.4 million Ebola cases by January 2015 if the viral disease kept spreading without effective methods to contain it. Belatedly, the international community stepped up efforts to control the outbreak, and the explosive growth slowed.

"Those predictions proved to be wrong, and it was not only because of the successful intervention in West Africa," King said. "It's also because the methods people were using to make the forecasts were inappropriate."

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Guinea shuts border with Sierra Leone in effort to end Ebola

ASSOCIATED PRESS by BOUBACAR DIALLO               March 30, 2015

CONKAKRY --Guinea closed its border with Sierra Leone on Monday as part of new efforts to stamp out Ebola, an official said.

... the disease remains stubbornly entrenched in Guinea more than a year after the outbreak started and authorities are now ramping up efforts to eliminate the disease.

Guinean President Alpha Conde announced this weekend that emergency measures would be "reinforced" for a 45-day period in five districts, including some along the border with Sierra Leone. The decision to close the border was made in the context of those new measures, according to Cmdr. Mamadou Alpha Barry, spokesman for the national gendarmerie.

Previously, Guinean authorities had monitored people crossing into the country for symptoms of the disease.

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http://www.charlotteobserver.com/living/health-family/article16925942.html

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The End of Ebola? Lessons at the Epidemic's One Year Anniversary

Columbia University                                            March 30, 2015

One year ago, the current Ebola epidemic was announced to the world. Since then, we have learned and accomplished an enormous amount....

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Sierra Leone’s 3-Day Ebola Lockdown is Over

Sierra Leone Ebola lockdown exposes hundreds of suspected cases

REUTERS                                                                                                      March 30, 015

(Scroll down for earlier story.)

FREETOWN - A three-day lockdown in Sierra Leone has exposed hundreds of potential new cases of Ebola, aiding efforts to bring to an end an epidemic that has already killed 3,000 people in the country.

Officials ordered the country's 6 million residents to stay indoors or face arrest during the period that ended late on Sunday as hundreds of health officials went door-to-door looking for hidden patients and educating residents about the virus.

Reports to authorities of sick people increased by 191 percent in Western Area, which includes the capital, during the lockdown compared with the previous weekend, said Obi Sesay of the National Ebola Response Center.

"Tests are being carried out on their blood samples, and the results will be in by Wednesday," Sesay said, adding that 173 of the patients in Freetown met an initial case definition for Ebola.

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