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Contest Seeks Novel Tools for the Fight Against Ebola

NEW YORK TIMES  by Donald G. McNeil, Jr.                                                                              Dec. 13, 2014

NEW YORK --The well-prepared Ebola fighter in West Africa may soon have some new options: protective gear that zips off like a wet suit, ice-cold underwear to make life inside the sweltering suits more bearable, or lotions that go on like bug spray and kill or repel the lethal virus.

A prototype for one of the protective suits in contention for the U.S.A.I.D. "Grand Challenges" award. Credit John Hopkins University/Jhpiego

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The Path to Zero Ebola Cases

Op-ed

NEW YORK TIMES by Jim Yong Kim, President of the World Bank Group      Dec. 11, 2014                                              

MONROVIA, Liberia — In my career as a medical doctor and global health policy maker, I have been in the middle of monumental struggles, including fights to make treatment accessible in the developing world for those living with H.I.V./AIDS as well as multi-drug resistant tuberculosis. But the Ebola epidemic is the worst I’ve ever seen...

Members of District 13 ambulance service disinfect a room in a village north of Monrovia, Liberia. Credit Jerome Delay/Associated Press

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Ebola experts seek to expand testing

A major problem is that relatively few laboratories in West Africa have the necessary equipment and personnel to test blood samples from people thought to have Ebola (see ‘Delayed diagnoses’). But that could soon change. Experts are gathering in Geneva, Switzerland, on 12 December to work out which diagnostic tools could be used wherever Ebola strikes.

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Experts call for faster mobilisation of “overlooked” survivors to contain Ebola epidemic

OXFORD UNIVERSITY PRESS                                                                                  Dec, 10, 2014

In an editorial published online today in the International Journal of Epidemiology, experts from the Departments of Psychiatry and Epidemiology at Columbia University, New York, are calling for survivors of the Ebola epidemic to be mobilised in a bid to hasten containment of the disease.

We already know that the current Ebola outbreak is unique in its magnitude and for its dispersion in dense, mobile populations. Physicians and nurses face high mortality, and foreign aid in the form of medical supplies and staff continues to be unequal to the scope of the problem. With a case recovery rate of around 30% at the present time in West Africa, survivors already number in the thousands.

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Rapid Ebola test is focus of NIH grant to Rutgers scientist

REPORTS Of RESEARCH ON TWO METHODS OF RAPID TESTING FOR EBOLA

(Two items, scroll down)

MEDICAL PRESS                                                                                     Dec. 8, 2014

Rutgers researcher David Alland, working with the California biotechnology company Cepheid, has received a grant of nearly $640,000 from the National Institutes of Health to develop a rapid test to diagnose Ebola as well as other viruses that can cause symptoms similar to Ebola.

Researchers will adapt this cartridge, now used worldwide for tuberculosis screenings, to collect and test samples from potential Ebola patients. Credit: John Emerson

Alland, a professor of medicine and associate dean for clinical research at Rutgers New Jersey Medical School and the principal investigator of the project, says would be able to take the test to small villages and other remote locations where the spread of Ebola has been especially rampant and diagnose patients where they live...

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How ‘phenomenal’ staff in Nigeria cut Ebola fatality rate in half

THE TORONTO GLOBE AND MAIL by Kelly Grant                Dec.7, 2014

When the World Health Organization declared Nigeria officially Ebola-free in October, most of the fanfare centred on how Africa’s most populous country had managed to keep the virus from spreading.

But there was another, less heralded aspect of Nigeria’s success story that a Canadian doctor and her colleagues wanted to explore in more depth: How had 12 of Nigeria’s 20 Ebola patients beaten the virus?

The hospitals in Nigeria weren’t maybe to the standards of a Western hospital in terms of equipment, but the staff were phenomenal. They managed to get a very high survival rate,” said Eilish Cleary, a New Brunswick chief medical officer of health who travelled to Nigeria to provide epidemiological support to the World Health Organization during the outbreak. “Case fatality rate for Ebola can be up to 70 to 90 per cent. In Nigeria, it was 40 per cent.”

Dr. Cleary conducted detailed, videotaped interviews with six of the Nigerian patients to learn more about their treatment and recovery. The key to their survival seemed to be guzzling a stunning amount of water with oral rehydration solution [ORS] to fend off the cascade of internal failures typically caused by the virus.

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What Ebola can teach us about a new bubonic plague outbreak in Africa

THE WEEK -- by S.E. Smith                                                                                                     Dec. 5, 2014
While West Africa battles Ebola, another outbreak is striking just across the continent. In Madagascar, cases of plague are erupting in the small village of Mandritsara and the disease is spreading to neighboring communities. The two outbreaks are related by more than simple surface similarities, though. In fact, fighting the first has provided an invaluable blueprint for containing the second.West Africa's Ebola outbreak could inform responders to Madagascar's plague cases.

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Cooler box-equipped motorbikes donated to UN will speed up Ebola testing process in West Africa

UNITED NATIONS NEWS CENTRE                                                                             Dec. 4, 2014
Four hundred motorbikes equipped with cooler boxes will help speed up deliveries of blood samples to laboratories from remote areas of Guinea, Liberia and Sierra Leone and reduce the waiting time for Ebola test results, thanks to a donation today from Germany to the United Nations.

Four hundred cooler box-equipped motorbikes for the Ebola Response were officially handed over to the UN Humanitarian Response Depot by German Ambassador to Ghana Ruediger John, and will be used to bring blood samples to labs in the most affected areas of Sierra Leone, Liberia, and Guinea. UNMEER Photo/Martine Perret

At UN Headquarters, meanwhile, UN Secretary-General Ban Ki-moon told reporters that the immediate priorities of the United Nations are to stop the virus and to treat all the people who have Ebola. “We have to ensure that all essential services are provided, and also we have to help them preserve their social and political stability, and keeping a further outbreak from happening.”

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What Ebola Is Teaching Us About Hard Trends

WIRED     Essay by David Burris                                                                                        Dec. 14, 2014

...Deadly and infectious viruses such as Ebola are an inevitable and unavoidable fact of nature. In other words, they are examples of a Hard Trend. And they demand new innovations in order to combat them.

...the deadly force of Ebola is the kind of imminent threat that inspires human minds to new heights. It teaches us that Hard Trends come at us fast and provide the catalyst to overcome inertia and bring about technological innovations.

NIAID/Flickr

Communication is key to mobilizing populations in countries affected by Ebola. In order to treat the sick and prevent the spread of the disease, healthcare workers need to be able to coordinate with people on the frontline and know where to send supplies. At the moment, telecommunications technologies are not keeping pace with the intense demands that Ebola creates.

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To halt Ebola's spread, researchers race for data

DISCOVER MAGAZINE    By Kari Lydersen                                                                              Dec. 2, 2014
.....redicting the trajectory of Ebola rather than playing catching-up could do much to help prevent and contain the disease. Some experts have called for prioritizing mobile treatment units that can be quickly relocated to the spots most needed. Figuring out where Ebola is likely to strike next or finding emerging hot spots early on would be key to the placement of these treatment centers.

But such modeling requires data, and lots of it.  And for stressed healthcare workers on the ground and government and non-profit agencies scrambling to combat a raging epidemic, collecting and disseminating data is often not a high priority.

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