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Experimental Ebola drugs should not be withheld, WHO says

World Health Organisation doubts feasibility of placebo-controlled trials in west Africa, but FDA favours ‘gold standard’

THE GUARDIAN                                                                                                           Nov. 6, 2014
By Sarah Bosley

Scientists involved in trials of experimental drug treatments for the Ebola epidemic in west Africa should not be compelled to withhold them from some patients, says the World Health Organisation, despite objections from the US that it is the only way to be sure they work.

Vials of the experimental VSE-EBOV vaccine for Ebola. Photograph: Mathilde Missioneiro/AP

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UT nasal spray vaccine for Ebola effective in monkeys

By Todd Ackerman                                                                           Nov. 5, 2014

... researchers at the University of Texas-Austin have developed a nasal spray vaccine that has protected monkeys against the deadly Ebola virus even a year after immunization.

The vaccine, a genetically engineered cold virus containing a tiny portion of Ebola DNA, saved 100 percent of monkeys who got a single spray through the nose in a new UT study. Injecting the vaccine only saved the lives of about 50 percent.

 
 
 Maria Croyle, a professor of pharmaceutics and the study's principal investigator, said an inhaled Ebola vaccine is more attractive because it would be cheaper and safer than needle-delivered vaccines.

"The main advantage is the long-lasting protection after a single inhaled dose," Maria Croyle, a  professor of pharmaceutics and the study's principal investigator, said in a statement. "This is important since the longevity of other vaccines for Ebola (hasn't been) fully evaluated....

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How Guinea Found the Best Way to Survive Ebola

TIME MAGAZINE                                         Nov. 5, 2014

by Alice Park

As the world waits for new treatrments and a vaccine. doctors in Guinea have found the best way to help patients survive Ebola.

... from the tragic illness and mortality emerge some important lessons from the region.The latest, published in the New England Journal of Medicine, details the cases that first appeared in Guinea’s capital city of Conakry between March and April. Unlike in other parts of the region, where the mortality rate from Ebola averages around 60% to 70%, in Conakry it has remained around 43%.

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Obama Seeks $6.2 Billion for Ebola Fight

UPDATE: Senate Appropriations schedules hearings for Wednesday, Nov. 12.

Moving quickly, the Senate Appropriation Committee announced it wil take up the administration's proposals at a hearng next Wednesday with a full slate of government officials from the key agencies. The committee will remaiend chaired bya  Democat, Senator Barbara Mikulski of Maryland, until the end of this Congressional session. The Republican controlled House Appropriations Committee has not yet announced hearings.

See Senate statement.

http://www.appropriations.senate.gov/news/chairwoman-mikulski-statement-funding-request-white-house-fight-ebola-here-and-abroad, 

Text of White House letter to Congress

http://www.whitehouse.gov/the-press-office/2014/11/05/letter-president-emergency-appropriations-request-ebola-fiscal-year-2015

See earlier story

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THE ASSOCIATED PRESS                                     Nov. 5, 2014

By JIM KUHNHENN and ANDREW TAYLOR

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Researchers Seek Crucial Tool: A Fast, Finger-Prick Ebola Test

NEW YORK TIMES                                  Nov. 5, 2014
By

Searching for a new way to attack Ebola, companies and academic researchers are now racing to develop faster and easier tests for determining whether someone has the disease.

A researcher checks an Ebola diagnostic test in Marcoule, France.  Credit Jean-Paul Pelissier/Reuters

Such tests might require only a few drops of blood rather than a test tube of it, and provide the answer on the spot, without having to send the sample to a laboratory.

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Asia must do more to help global Ebola fight - World Bank

REUTERS                                            Nov. 4, 3014
ByJames Pearson

SEOUL, Korea --lAsian countries are not contributing enough to the global effort to fight Ebola, despite having a wealth of trained medical personnel who could help stop the spread of the deadly virus, World Bank Group president Jim Yong Kim said on Tuesday.

World Bank Group president Jim Yong Kim (L) listens to a reporter's question during a news conference in Seoul   November 4, 2014. Credit: Reuters/Kim Hong-Ji

"Many countries in Asia who could help simply are not, especially when it comes to sending health workers," Kim told a news conference in Seoul....

"We need thousands of health workers, and we're going to need them over the next six months to a year. The fight against Ebola is not over until we get to zero cases in those three countries," Kim said.

Read complete story

http://uk.reuters.com/article/2014/11/04/uk-health-ebola-asia-idUKKBN0IO0BJ20141104

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Treating Ebola: The Bluetooth Method

Keeping hands-off without abandoning the patient.

NATIONAL GEOGRAPHIC                               Nov. 3, 2014
By Melissa Pandika

Description of the way that the University of Nebraska Medical Center, which has successfully treated two Ebola patients, uses blue tooth technology and the " no-touch approach."

Members of the Department of Defense's Ebola Military Medical Support Team dress with protective gear during training at San Antonio Military Medical Center in San Antonio. Photograph by Eric Gay, AP

Read complete story

http://news.nationalgeographic.com/news/2014/11/141106-science-ebola-cure-medicine-health-africa-disease-technology/

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Structural Adaptivity, Before and After Thoughts

 

As a means of concluding these writings on Structural Adaptivity and Resilience, following are some of the background thoughts, with recent revision, that led me to my proposals. Originally, my writings were directed at city and regional planning. However now I realize they are also about resilience.  I hope my submittals will be helpful.  I will try to write more soon.

 

Time.  Planners, resilience makers, and all other leaders and professionals dealing with the built environment must focus on long time spans.  In order to have significant impact on the future of our world, we must recognize that only by looking at big chunks of history and big chunks of future time can we really see the reality of what is going on.  Likewise, we need to do so in order to see the reality of what needs to be done.

 

Typical urban or regional plans target a future some 20 years ahead.  Moreover, they typically are based on past trends of 20 years or so.  However, our world does not change in 20-year cycles.  Twenty years is a very short time period in the flow of transformation.

 

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Emergency Preparedness: Ebola Outbreak Response

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MedEdPORTAL                                        Nov. 3, 2014

The Association of American Medical Colleges (AAMC),in response to the Ebola, outbreak, has created on its  MedEdPORTAL created this collection of peer-reviewed teaching materials, new and innovative resources (non peer-reviewed), and online continuing education activities for practicing healthcare providers focused on emergency preparedness for outbreaks.

Hospital Records Are Adapting to Flag Ebola

A New Application Matches Patient’s Travel and Family History With Medical Symptoms

WALL STREET JOURNAL                         Nov. 3, 2014
By Melina Beck

A month ago, Massachusetts General Hospital in Boston had no way to flag in its electronic medical records if an incoming patient had been to West Africa and had symptoms suggesting Ebola.

Now it does. Five days after the first U.S. case was confirmed in Texas, the hospital deployed a new Ebola application made by QPID Health Inc. that automatically matches a patient’s travel and family history with medical symptoms. If Ebola is suspected, the application flashes a blinking “Q” to alert hospital personnel.

Dr. Garry Choy, who helped design Mass General’s QPID system. Dominick Reuter

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