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Pregnant Ebola patient may have been contagious for days without symptoms

REUTERS by Gene Emery                                                                         June 18, 2015

 NEW YORK (Reuters Health) - Pregnant women infected with Ebola may be contagious for days before they show symptoms, a group of doctors is warning in the June 18 New England Journal of Medicine.

The warning is based on a single case and the woman did not actually spread the deadly infection to anyone. But laboratory tests revealed high levels of the virus when no symptoms were present.

Usually people aren't considered to be contagious until they start to feel ill.

The reason pregnant women may be an exception may have to do with the way pregnancy affects the woman's body, the doctors say. Her immune system becomes more tolerate of the fetus, whose tissues would normally be considered foreign.

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http://news.yahoo.com/pregnant-ebola-patient-may-contagious-days-without-symptoms-124114264.html;_ylt=AwrC0wxAAYNVTlEAmp7QtDMD;_ylu=X3oDMTBybGY3bmpvBGNvbG8DYmYxBHBvcwMyBHZ0aWQDBHNlYwNzcg--

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Ebola genetic code analysed to show evolution of worst ever outbreak

THE GUARDIAN   by Ian Sample                                                                             June 18, 2015

Scientists have analysed the genetic code of Ebola viruses from patients across west Africa and pieced together the evolution of the worst ever outbreak of the killer disease.

Experts from Public Health England at Porton Down in Britain, the World Health Organisation (WHO), and other leading labs, used DNA from 179 Ebola samples to reconstruct the spread of the virus from Guinea into surrounding countries last year.

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Blood, Sweat and Tears: Study Will Watch Ebola Survivors

NBC NEWS   by Maggie Fox                              June 17, 2015         

Does Ebola stay in your eyes after you recover? Can it spread via semen? Why does it cause achey joints?

U.S. researchers are launching a study in Liberia to take a look at survivors of the deadly virus to see just how common these long-term effects are, and whether they contribute to outbreaks.

"To unravel the many unknowns, we have expanded the focus of our partnership with Liberia's Ministry of Health to include research on the long-term health effects of Ebola virus disease, in addition to our ongoing efforts to find an effective preventive vaccine and treatments for Ebola virus disease," said Dr. Tony Fauci, director of the National Institute of Allergy and Infectious Disease.

Liberia's health ministry and the NIAID will be studying 1,500 Ebola survivors and 6,000 of their close contacts. They'll look at sweat, tears, semen and other bodily fluids in the survivors and follow everyone for as long as five years.

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Why Some Ebola Strains Are More Dangerous Than Others

CHEMISTRY WORLD by Christopher Barnard             June 17, 215
The virulence of Ebola virus strains appears to be innately linked to the degree of disorder in proteins that form their nucleocapsids. Computational analysis has revealed that strains responsible for the most lethal outbreaks of Ebola show significantly higher levels of intrinsic protein disorder than less virulent strains, in a discovery that could constitute a major breakthrough in understanding the pathogen’s behaviour.

With over 27,000 confirmed, probable and suspected cases and more than 11,000 fatalities worldwide, the ongoing Ebola outbreak has resulted in considerably more casualties since late 2013 than all other outbreaks combined. There are no effective treatments or vaccines against the haemorrhagic fever that evinces Ebola infection; however, strains of the virus with drastically different virulence have emerged since the first outbreak in 1976, with fatality rates ranging from 25 to 90%.

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Ebola vaccines in limbo expose need for more speed in trials

REUTERS by Kate Keller and Ben Hirschler                                      June 17, 2015

LONDON --Drugmakers' plans to conduct vast clinical trials to test and hopefully validate the first Ebola vaccines have been thwarted by success in beating back the deadly epidemic in West Africa.

GlaxoSmithKline, Merck and Johnson & Johnson are struggling to recruit volunteers with enough exposure to the disease to prove whether their vaccines are doing the job and preventing infection.

The story might have been very different with just another three or four months of disease spread, underscoring the need to act more quickly to develop vaccines for emerging diseases....

Guinea, where Ebola is still infecting new victims, as "the only hope" for showing efficacy, according to Kieny and to Adrian Hill, director of the Jenner Institute at Britain's Oxford University.

The WHO is overseeing the so-called ring vaccination study in Guinea in which close contacts and family around each new case of Ebola are vaccinated -- either immediately or after a three-week delay -- to see if the shot offers protection.

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Turn on the taps to defeat the next Ebola

IRIN by Jennifer Lazuta                                 June 15, 2015

DAKAR, Senegal - It is a cruel irony that many of the top doctors and nurses in Guinea, Liberia and Sierra Leone will not be around to help rebuild their health systems in the wake of Ebola, having succumbed themselves to the virus.

Many families in Guinea still rely on streams and lakes for their water needs.Photo: Jennifer Lazuta/IRIN

 For those that are, the biggest challenges are likely to be electricity, sanitation, and, most of all, water.

“How is it possible to build, or rebuild, as you may call it, a health institution or hospital without [access to] water, which serves as a major catalyst to run the facility?” asked Moses Tamba, a spokesperson for Liberia’s Ministry of Public Works. “It is not possible. You need water....”

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Seeking the Source of Ebola

The latest Ebola crisis may yield clues about where it hides between outbreaks.

GLOBAL LITERACY PROJECT                                       June  15, 2015
abstract of article in
   
(Scroll down for full article.)       

   Picture of a masked bush meat hunter. Peter Muller.

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The Case for Improved Diagnostic Tools to Control Ebola Virus Disease in West Africa and How to Get There

PLOS by Arlene C. Chua,Jane Cunningham,Francis Moussy, Mark D. Perkins,and Pierre Formenty      June 11 2015

 ...Since the identification of Ebola in Guinea in March 2013, rapid deployment of international mobile laboratories through WHO networks—Global Outbreak Alert and Response Network (GOARN) [2] and Emerging and Dangerous Pathogens Laboratory Network (EDPLN) [3]—has been vital to outbreak control operations. Deployable laboratories from multiple international organizations have been established near Ebola treatment centers (ETC) in Guinea, Liberia, and Sierra Leone....

However, several technical and social factors conspire to delay diagnosis, starting with weak surveillance systems and slow patient access to centralized ETCs. While the mean processing time is 5 hours (time difference from when samples are received in the laboratory to when they are tested), there is a marked difference in the time from when the samples are collected from suspected patients to the time they are received by the laboratory

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How close is the Ebola vaccine?

PUBLIC BROADCASTING CORP by Caleb Hellerman         June 11, 2015

The quest for an Ebola vaccine has been a journey filled with excruciating delays and mad dashes. The latest outbreak in West Africa caused governments and drug companies to jumpstart research that had languished back when the threat of Ebola wasn’t big enough to sustain a commercial market. (Prior to 2013, the virus had sickened fewer than 2,300 people in known history). Human safety trials of two vaccines began last summer — each being given to a small group of healthy volunteers. When no major side effects were apparent, health officials scrambled to launch larger tests in the countries that were most affected by Ebola.

A volunteer receives an Ebola vaccine in Sierra Leone. Thousands of these voluntary immunizations have been tested so far in the West African nation. Photo by Cameron Hickey.

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Ebola Stigma Keeps Many From Work in Liberia

VOICE OF AMERICA — by Chris Stein and  Prince Collins  June 11, 2015

DAKAR and  MONROVIA --Burial teams undertook some of the most hazardous work in Liberia’s fight against Ebola. With the West African nation now getting relief from the virus, these men and women say societal stigma is keeping them from getting jobs....

Being unemployed is no small thing in Liberia, which was already recovering from nearly two decades of ruinous civil war before Ebola broke out in 2014.

About two-thirds of Liberians live in poverty, according to the World Bank. Sonny Fayon was unemployed when the outbreak started, he found work on a burial team, but now is out of a job again. Even though he never got sick, no one will hire him, he said.

“We’re not very vulnerable to the Ebola business. We’re well-protected, we wore protective clothing to do the job,” Fayon stated. “So they should accept us. I think we were very careful in doing the work.”
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