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New Ebola trial vaccine 'safe': researchers

AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

 But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

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http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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Ebola Diaries: Hitting the Ground Running

INFECTION CONTROL TODAY                                      March 24, 2015
The World Health Organization (WHO) is publishing a series, "Ebola Diaries," with first-person accounts of WHO staff and others deployed to the field for Ebola response since the first cases were reported in West Africa on March 23, 2014.
 
Dr. Stéphane Hugonnet, team lead for gobal capacities, alert and responses for the World Health Organization (WHO), was one of the first WHO experts sent to Guinea to investigate cases of Ebola reported in late March 2014. A medical doctor who has spent the past 20 years working for WHO, MSF and others, managing outbreaks ranging from cholera, measles and yellow fever, to Lassa, Ebola and meningitis, Hugonnet found a very different sort of outbreak when he arrived in Guinea.

"We were following this rumor of a small cluster of unexplained deaths in Guinea," he says. "Some thought it could be Lassa    phane fever, but the transmission pattern was very compatible with Ebola. When the lab results came back, we learned that there was Ebola Zaire in West Africa.            

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Fighting Ebola with a holistic vision of big data

TECH REPUBLIC  by Mary Shaklett                                                                         March 24, 2015

Big data practitioners are learning that the laboratory know-how of computer scientists and statisticians must be matched with a holistic, 360-degree vision of the problem to be solved. TheEbola crisis is a prime example....

If big data is going to help solve health issues like Ebola, it must be incorporated into analytics that consider all of the factors shaping the epidemic. These are three of the ingredients that should be factored into Ebola analytics.

1: There are political barriers that stand in the way of obtaining data from cell phone providers that could assist researchers in determining where the disease will strike next.

2: Even if disease researchers could obtain this data, there is a need to "correct" the data for what it doesn't reveal. For example, if less than 50% of a country's population has access to mobile phones and individuals are constantly moving from village to village, how will researchers be able to verify the quality of the data they're getting unless there are people "on the ground" who can verify or provide corrective factors to the data?

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As Ebola Crisis Ebbs, Aid Agencies Turn To Building Up Health Systems

NATIONAL PUBLIC RADIO by Nurith Aizenman                March 23, 2015

Recruiting and training new health workers is key, because experts warn that unless the health systems in West Africa are brought up to scratch, an epidemic on the scale of this one will happen again.

A nurse walks near the empty children's ward at Redemption Hospital in New Kru Town, Monrovia, Liberia. David Gilkey/NPR

Unfortunately, building national health systems doesn't tend to attract a lot of love from international donors, says Erin Hohlfelder, who's been pushing for this kind of funding on behalf of the ONE Campaign, a global health advocacy group.

"It's certainly not as 'sexy' — quote unquote — as things like treatment for HIV or bed nets for malaria, which are very tangible and easy to understand."

She says at least for now, the international community does seem to get the importance of building up West Africa's health systems. The governments of the affected countries are preparing national plans to present at a meeting of the World Bank next month

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Guinea Trial Begins for Suspected Killers of Ebola Workers

ASSOCIATED PRESS by Boubacar Diallo                    March 23, 2015

The trial highlights the challenges health workers faced in this Ebola outbreak that has claimed more than 10,000 lives, mostly in the impoverished West African nations of Guinea, Sierra Leone and Liberia.

Around 78 suspects are being tried in the town of N'Nzerekore, 900 kilometers (560 miles) from the capital Conakry, Ministry of Justice spokesman Ibrahima Beavogui said.

The killings happened when a delegation of health care workers, including top health officials from the nearby town, visited Womey last September to raise awareness about how to combat Ebola. They were attacked by a mob armed with knives and stones.

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Ebola outbreak 'over by August', UN suggests

BBC   by  Smitha Mundasad                                                                                        March 23, 2015

The Ebola outbreak in West Africa will be over by August, the head of the UN Ebola mission has told the BBC.

 

 Ismail Ould Cheikh Ahmed admitted the UN had made mistakes in handling the crisis early on, sometimes acting "arrogantly".

A year after the outbreak was officially declared, the virus has killed more than 10,000 people...

The head of the UN Ebola response mission told the BBC, when the virus first struck, "there was probably a lack of knowledge and there was a certain degree of arrogance, but I think we are learning lessons.

"We have been running away from giving any specific date, but I am pretty sure myself that it will be gone by the summer."

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http://www.bbc.com/news/health-32009508

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Slow International Response to Ebola Epidemic Cost Thousands of Lives: MSF

TIME MAGAZINE  by Helen Regan                                March 23, 2015
(Scroll down for link to full MSF report.)

Paris-based Doctors Without Borders (MSF) has slammedthe international community’s slow response to the Ebola outbreak in West Africa, saying it cost thousands of lives that could otherwise have been saved.

A Doctors Without Borders (MSF), health worker in protective clothing carries a child suspected of having Ebola in the MSF treatment center on October 5, 2014 in Paynesville, Liberia.

The leading international medical charity released a report Monday coinciding with the one-year anniversary of the outbreak’s start. It said warnings that the disease’s spread was out of control were dismissed as alarmist and that early calls for help were ignored by local governments and the World Health Organization (WHO), reports Reuters.

“For the Ebola outbreak to spiral this far out of control required many institutions to fail. And they did, with tragic and avoidable consequences,” said MSF’s general director Christopher Stokes in the report.

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One Year Later, Ebola Outbreak Offers Lessons for Next Epidemic

IN DEPTH OVERVIEW OF THE EBOLA CRISIS AND LESSONS FOR THE FUTURE
NEW YORK TIMES  by Sheri Fink, MD,   and Pam Belluck                                     March 23, 2015

One year has passed since the declaration of what became the largest Ebola outbreak in history, with more than 10,000 deaths..

Assessing the lessons of an Ebola outbreak that became the largest in history, with 10,000 dead. Credit Daniel Berehulak for The New York Times

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