Situation Report

Kids in Liberia go back to school — in a building where dozens died of Ebola

              Parents resister pupils at Massaquoi less than a month after the last Ebola patient left the school.

WASHINGTON POST   by Martin Sieff                                                                             Feb. 1, 2015

MONROVIA--As the Ebola epidemic fades here, with fewer than 10 new cases reported per week, Liberia is beginning the massive challenge of resuming normal life. Many of its public institutions have been shuttered since June. Its economy has been paralyzed. More than 3,600 Liberians have died of the disease.

Those who endured the crisis are now grappling with a new set of predicaments: whether to sleep in the rooms where relatives died, to have babies in hospitals where Ebola patients were treated. In a country where containing Ebola meant persuading people to fear it, the public may remain traumatized for some time to come.

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As Ebola Ebbs in Africa, Focus Turns From Death to Life

NEW YORK TIMES  by Normitsu Onishi                                                                Feb. 1, 2015

MONROVIA, Liberia — Life is edging back to normal after the deadliest Ebola outbreak in history....

FEAR FADING Beachgoers in Monrovia, Liberia, recently ravaged by Ebola. As fear of the virus ebbs, Liberians are slipping back into their daily rhythm. John Moore/Getty Images

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Ebola crisis update - 30 January 2015

Médecins Sans Frontières                                                                   Jan 30, 2015

During the last weeks, a downward trend of new cases has been reported in Médecins Sans Frontières (MSF) Ebola management centres across the three affected countries, with 50 confirmed cases in its eight centres last week.

While this is a promising development, the World Health Organization reported that only about half of new cases in both Guinea and Liberia are from known Ebola contacts, while in Sierra Leone there is no data available. There is almost no information sharing for tracing Ebola contacts between the three most-affected countries.

Since a single new case is enough to reignite an outbreak, the level of vigilance should remain high in order not to jeopardise the progress made in stemming the epidemic....

Read complete update:
http://www.msf.org/article/ebola-crisis-update-30-january-2015

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What worked in controlling the Ebola outbreak in West Africa

One Lesson: Rush to Help, not to declare victory

EDITORIAL    THE WASHINGTON POST                                Jan. 31, 2015

THE WORLD’S tardy response to the Ebola virus outbreak in West Africa, which has killed 8,810 people, demands that lessons be learned.

 Toward that end, a fresh batch of scientific reports has emerged in recent days to guide future responses. The World Health Organization, which stumbled in the initial period, seems to be recognizing its mistakes and looking for ways to correct them.... it is vital to keep medical interventions in place for long periods — and a big mistake to declare victory too early. The research also shows that most transmission of Ebola occurred in families....

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Ebola crisis: Liberia delays school re-opening

BBC                                                                                               Jan. 30, 2015

Liberia has delayed planned re-opening of schools, saying they are not not yet fully prepared to prevent the spread of Ebola.

The schools - closed in July - had been due to open on Monday, but teaching will now begin on 16 February.

The BBC's Mark Doyle says several schools he has seen are woefully unready to prevent Ebola infection.

He says they are lacking chlorinated water for hand-washing and thermometers to check pupils don't have fever.

Read complete story.
http://www.bbc.com/news/world-africa-31068706

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Ebola likely to persist in 2015 as communities resist aid: Red Cross

REUTERS  by  Stephanie Nebehay                                                                                   Jan. 30, 2015

GENEVA --West Africa will be lucky to wipe out Ebola this year, as the local population remains suspicious of aid workers, especially in Guinea, the Red Cross said on Friday.

 

 Healthcare workers prepare to disinfect an ambulance transporting a newly admitted Ebola patient at the entrance to the Save the Children Kerry Town Ebola treatment centre outside Freetown, Sierra Leone in this file photo taken on December 22, 2014. Credit: Reuters/Baz Ratner

The virus is "flaring up" in new areas in the region and not all infections are being reported, said Birte Hald, who leads the Ebola coordination and support unit of the International Federation of Red Cross and Red Crescent Societies.

"We are also seeing that in places like Sierra Leone and especially in Guinea that it is flaring up in new districts all the time, with small new chains of transmission, which means that it's not under control and it could flare up big-time again," Hald told a news briefing in Geneva.

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Global Health Security: The Next Five Years

onlinedigeditions.com - Andrew C. Weber - Christine Parthemore

The next five years will see crucial changes in the global health security landscape, profoundly shaped by two key events in 2014:

The Ebola response in West Africa, and the successful first year of the Global Health Security Agenda, an initiative of dozens of countries and non-governmental organizations to make tangible commitments for preventing, rapidly detecting, and effectively responding to infectious disease threats.(1) 

Both events brought to light signs of measurable progress, and profound gaps that must be prioritized in the years ahead. Pressing needs include expanding emergency operations center capacity, better leveraging technological innovation, and closing the gap between the health and security communities.

(READ COMPLETE ARTICLE)

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Ebola outbreak: Virus mutating, scientists warn

Scientists tracking the Ebola outbreak in Guinea say the virus has mutated.

Researchers at the Institut Pasteur in France, which first identified the outbreak last March, are investigating whether it could have become more contagious.

They are tracking how the virus is changing and trying to establish whether it's able to jump more easily from person to person

"We know the virus is changing quite a lot," said human geneticist Dr Anavaj Sakuntabhai.

It's not unusual for viruses to change over a period time. Ebola is an RNA virus - like HIV and influenza - which have a high rate of mutation. That makes the virus more able to adapt and raises the potential for it to become more contagious.

Read complete story.

http://www.bbc.com/news/health-31019097

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There's an Ebola Vaccine in Africa. Now What?

A scanning electron micrograph of the Ebola virus. The first large-scale trials of an Ebola vaccine are underway in Africa.(NIAID / Flickr)

Unprecedented: In four months, the Ebola vaccine has gone from concept to field trial. Success is not assured.

 THE NATIONAL JOURNAL  by Brian Resnick                      Jan. 28, 2015

Detailed description of the problems issues and procedures for fieldingand testing Ebola vaccines in West Africa.

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..."Without the (Ebola) virus circulating, there's no way to prove the vaccine is effective. At current infection rates, trial researchers would need to see 100 cases of Ebola over a four-month period to achieve statistical significance. That time frame may stretch, or fall apart altogether.

"It's a real dilemma," says Margaret Harris, an MD and spokeswoman for the World Health Organization. "It's extremely good news that the cases are coming down, but it does mean we may not have clear phase III data."

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An experimental Ebola vaccine looks promising in a human trial

Vaccine  was made by introducing an Ebola gene in a chimpanzee cold virus

THE VERGE    by Arielle Duhaime-Ross                                                             Jan. 28, 2015

An Ebola vaccine produced using a chimpanzee common cold virus appears to be safe to use on humans, according to a study published today in the New England Journal of Medicine. Three different doses of vaccine were tested on healthy humans in the UK, and it was well-tolerated; it triggered high levels of antibody formation without also triggering serious side effects. But until the vaccine is tested in an area where an Ebola risk actually exists, it’s efficacy against the disease will remain a mystery.

Read complete story.
http://www.theverge.com/2015/1/28/7930947/ebola-vaccine-human-trials-results

A Monovalent Chimpanzee Adenovirus Ebola Vaccine — Preliminary Report

 New England Journal of Medicine

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