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This working group is focused on discussions about health.

The mission of this working group is to focus on discussions about health.

Members

Corey Watts John Girard jonber37 Kathy Gilbeaux Lisa Stelly Thomas Maeryn Obley
mdmcdonald MDMcDonald_me_com mike kraft

Email address for group

health-us@m.resiliencesystem.org

Ebola Free-for-All Could Trigger Bad Science and Wasted Efforts

Everybody and his uncle, it seems, has an idea of something that might work to cure people infected with the deadly virus

 SCIENTIFIC AMERICAN    By Helen Branswell                        Dec. 4, 2014

When it comes to treatments for Ebola, there has been a nearly four-decade-long drought. Nothing in the medical arsenal attacks the virus directly....

 

 

 

Dr. John M. Dye, Jr., U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Viral Immunology branch chief, works in a laboratory at the USAMRIID headquarters in Frederick, Maryland. Dr. Dye is leading a team that is conducting a study with nonhuman primates involving the experimental drug ZMapp, an experimental treatment for Ebola patients. Credit: CDC

 

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Pentagon Scaling Back Military Effort to Contain Ebola

MILITARYNEWS.COM  by Richard Sisk                            Dec. 3, 2014

The U.S. military was scaling back its efforts against Ebola in Liberia amid encouraging signs of progress against the epidemic, Army Gen. David Rodriguez said Wednesday.

 

U.S. personnel construct the Monrovia Medical Unit site in Monrovia, Liberia. The MMU is being constructed in the event any medical workers in the area catch Ebola while assisting in Operation United Assistance. Craig Philbrick/Army

The military initially planned to construct 17 treatment centers of 100 beds each in Liberia, but will now set up 10 centers for virus victims. The first three centers will have 100 beds, but the remaining seven will have 50 beds, Rodriguez, head of U.S. Africa Command, said at a Pentagon briefing.

Rodriguez also said the military was looking at possibly easing the 30-day quarantine period for troops returning from West Africa. However, he stressed that no decisions had been made.

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Health-Care Worker Who May Have Ebola Arrives in Atlanta

BLOOMBERG--By Andrew Pollack and Doni Bloomfield                                                                  Dec.4, 2014

ATLANTA-- An American health worker who may have been exposed to the Ebola virus arrived at an Atlanta hospital today for possible treatment after being evacuated by air from West Africa, where the outbreak is at its worst.

The health worker, who hasn’t been publicly identified, was admitted this morning at Emory University Hospital, which has successfully treated four other Ebola patients, the hospital said in an e-mail.

“Emory cannot share more details out of respect for patient privacy and in accordance with the patient’s wishes,” the hospital said. Phoenix Air, a medical charter company, flew the patient from West Africa, according to the statement. Earlier this week, Emory was named one of 35 U.S. hospitals designated to treat Ebola patients.

Emory didn’t say in what country the health worker may have been exposed.
Read complete story.

http://www.bloomberg.com/news/2014-12-04/health-care-worker-who-may-have-ebola-headed-to-u-s-.html

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Evaluating Ebola Therapies — The Case for RCTs

THE NEW ENGLAND JOURNAL OF MEDICINE                                                                                 Dec. 3, 2014
By Edward Cox, M.D., M.P.H., Luciana Borio, M.D., and Robert Temple, M.D.

...Studying investigational therapies for EVD presents scientific, practical, and ethical challenges. Not surprisingly, there has been substantial debate about the best and most appropriate study approaches.2,3 It is generally agreed that a trial with a concurrent control group, in which patients are randomly assigned to receive the test drug plus the best available supportive care (BASC) or to BASC alone, would be the most efficient and reliable way to evaluate the safety and effectiveness of candidate products.

 Some people in the health care community, however, have argued against such trials, urging instead use of a historical control — that is, making investigational drugs as widely available as their supply allows and then comparing mortality rates among treated patients with rates that would have been expected absent the drugs, on the basis of past experience with EVD.

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Positive results spur race for Ebola vaccine

With trials under way, scientists are working out how to give vaccines in affected regions

NATURE   By Ewan Callaway                                                                                                 Dec. 2, 2014

Safety trials of Ebola vaccines are starting to return results: at least one is known to be safe and to summon an immune response against the virus.

The challenge now is to use the results to guide the larger studies that will reveal whether the vaccines work.

“The immune responses are there,” says infectious-disease researcher Adrian Hill, director of the Jenner Institute in Oxford, UK. “The tough call is whether they’re enough to protect humans against Ebola.”

Read complete story

http://www.nature.com/news/positive-results-spur-race-for-ebola-vaccine-1.16468

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To halt Ebola's spread, researchers race for data

DISCOVER MAGAZINE    By Kari Lydersen                                                                              Dec. 2, 2014
.....redicting the trajectory of Ebola rather than playing catching-up could do much to help prevent and contain the disease. Some experts have called for prioritizing mobile treatment units that can be quickly relocated to the spots most needed. Figuring out where Ebola is likely to strike next or finding emerging hot spots early on would be key to the placement of these treatment centers.

But such modeling requires data, and lots of it.  And for stressed healthcare workers on the ground and government and non-profit agencies scrambling to combat a raging epidemic, collecting and disseminating data is often not a high priority.

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Obama: Ebola still priority as public focus shifts

ASSOCIATED PRESS                                                                                                        Dec. 2, 2014 

BETHESDA, Maryland  — Declaring the "fight is nowhere close to being over," President Barack Obama on Tuesday heralded strides in the effort to confront Ebola in West Africa and in protecting the U.S. against the spread of the deadly virus. He said squelching the disease remains an urgent priority even if the American public's attention has shifted elsewhere.

"We cannot let down our guard, even for minute," Obama said. "We can't just fight this epidemic, we have to extinguish it."

Obama spoke after touring the National Institutes of Health in Washington's Maryland suburbs where he witnessed advances in Ebola-fighting research. He highlighted the NIH's progress in developing an Ebola vaccine, calling the initial results "exciting" while cautioning that there are "no guarantees" about the vaccine's ultimate success.

NIH researchers last week reported that the first safety study of a vaccine candidate found no serious side effects, and that it triggered signs of immune protection in 20 volunteers. U.S. health officials are planning much larger studies in West Africa to try to determine if the shots really work...

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U.S. designates 35 hospitals to treat Ebola patients

WASHINGTON POST-- By Lena H. Sun                                                                                         Dec. 2, 2014

WASHINGTON --U.S. officials have designated 35 hospitals around the country to care for Ebola patients, part of the Obama administration’s effort in the past two months to improve domestic preparedness to cope with the deadly virus that has ravaged West Africa.

 

A nurse walks down a hallway alongside a patient care room in a new custom-built bio-containment unit for potential Ebola cases at Mount Sinai Hospital, in New York. (John Minchillo/AP)

 The hospitals were chosen by state health officials and hospital executives and assessed by infection control teams from the Centers for Disease Control and Prevention to make sure they have adequate staff, equipment, training and resources “to provide the extensive treatment necessary to care for an Ebola patient,” according to a senior administration official.

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Ebola Response Too Slow, Group Warns

World Bank Meanwhile lowers growth forecasts.

(See link below to World Bank Report)

ASSOCIATED PRESS                                                                                               Dec. 2, 2014
By JONATHAN PAYE-LAYLEH and SARAH DiLORENZO

MONROVIA, Liberia (AP) — The international response to Ebola is still too slow and piecemeal, Doctors Without Borders warned Tuesday, as officials said the disease is crippling the economies of the three West African countries hardest hit....

"Foreign governments have focused primarily on financing or building Ebola case management structures, leaving staffing them up to national authorities, local health care staff and NGOs (non-government organizations) which do not have the expertise required to do so," said the group, which is a primary provider of treatment in the outbreak, said in a statement Tuesday.

It reiterated its call for countries with biological-disaster response teams to deploy them.

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2014 Goals for Ebola Treatment May Not Be Met, U.N. Health Officials Say

NEW YORK TIMES  By Sheri Fink and  Somini Sengupta                                                       Dec. 2, 1014

GENEVA — The World Health Organization expressed doubt on Monday about achieving important United Nations benchmarks in battling Ebola, saying the year-end goals of isolating and treating all patients and safely burying all the dead would be major challenges.

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