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Experts call for faster mobilisation of “overlooked” survivors to contain Ebola epidemic

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OXFORD UNIVERSITY PRESS                                                                                  Dec, 10, 2014

In an editorial published online today in the International Journal of Epidemiology, experts from the Departments of Psychiatry and Epidemiology at Columbia University, New York, are calling for survivors of the Ebola epidemic to be mobilised in a bid to hasten containment of the disease.

We already know that the current Ebola outbreak is unique in its magnitude and for its dispersion in dense, mobile populations. Physicians and nurses face high mortality, and foreign aid in the form of medical supplies and staff continues to be unequal to the scope of the problem. With a case recovery rate of around 30% at the present time in West Africa, survivors already number in the thousands.

In their editorial, Dr Zena Stein of the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Joseph Mailman School of Public Health at Columbia University, and her colleagues, who are based at the HIV Center for Clinical and Behavioral Studies at the New York State Psychiatric Institute and Columbia University, lay out four major reasons why Ebola survivors may be critical to controlling the epidemic:

Read complete articles.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=147987&CultureCode=en

Link to International Journal of Epidemiology, doi: 10.1093/ije/dyu233

http://ije.oxfordjournals.org/content/early/2014/12/05/ije.dyu233.short?rss=1

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CDC  EMERGING INFECTIOUS DISEASES JOURNAL    by Thomas R. Kreil                                        Dec. 11, 2014

Clinical evidence suggests that antibodies from reconvalescent donors (persons who have recovered from infection) may be effective in the treatment of Ebola virus infection. Administration of this treatment to Ebola virus–infected patients while preventing the transmission of other pathogenic viruses may be best accomplished by use of virus-inactivated reconvalescent plasma....

Supported by scarce yet positive clinical evidence (1) and some recent animal model data (2), the use of whole blood or plasma transfusions from reconvalescent donors (persons who have recovered from Ebola infection) that contain antibodies to the Ebola virus has received substantial (also media) attention as a treatment alternative. However, several aspects associated with this approach need consideration to potentially enable treatment at a scale reasonably commensurate to the ongoing outbreak and at a level of safety with respect to the possible transmission of viruses that is consistent with currently accepted standards. The primary choice among options would be between use of whole blood or plasma only.

Read full paper.
http://wwwnc.cdc.gov/eid/article/21/3/14-1838_article

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