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CENTER FOR DISEASE RESEARCH AND POLICY        July 24, 2015

(Also scroll down for: Ebola case definition quandary; Public health worker Ebola unease)

Researchers found that the World Health Organization (WHO) Ebola case definition has a specificity of only 31.5%, and they noted that 9% of Ebola patients reported neither a fever nor any Ebola risk exposure, calling into question WHO norms, according to a large study yesterday in The Lancet Infectious Diseases.

Researchers from Britain and Sierra Leone analyzed data on 850 suspected and 724 lab-confirmed Ebola patients who presented to the holding unit of Connaught Hospital in Freetown from May 29 to Dec 8, 2014. Fever or history of fever (n=599, 83%), intense fatigue or weakness (495, 68%), vomiting or nausea (365, 50%), and diarrhea (294, 41%) were the most common presenting symptoms in suspected cases.

Based on data from these patients, the investigators found the sensitivity of the WHO case definition to be 79.7%, which means about 20% of true Ebola cases would be missed (false-negatives). They found the specificity of the case definition to be 31.5%, which means 68.5% of patients who would be selected for admission would not actually have Ebola virus disease (false-positives).

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REUTERS   July 14, 2015

MONROVIA - A Liberian woman has died of Ebola in a hospital in Monrovia shortly after being admitted, becoming the sixth confirmed case of the virus since it resurfaced last month after a seven-week lull, a senior medical official said on Tuesday.

The victim from Montserrado County, which contains Monrovia, is thought to be linked to the other five cases from neighboring Margibi County, where the disease reemerged.

Her detection raised fears that the infection may be spreading in a new area of the country.

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http://news.yahoo.com/liberia-confirms-ebola-case-outbreak-spreads-120753593.html

Side Event in Support of the UN Secretary-General’s International Ebola Recovery Conference July 9-10 2015

United Nations Headquarters - Conference Room 3, 13.15-14.30 pm (1:15pm-2:30pm, ET), 10 July 2015

As a side-event in support of the United Nations Secretary-General’s International Ebola Recovery Conference, Ebola Innovation for Impact 2015: Game Change in Global Health Crisis Management will bring together thought leaders in global health and technology to stimulate creative, collaborative and catalytic action, and to address the Ebola crisis with innovative solutions in the key, inter-linked areas of: Community Engagement and Mobilization; Private Sector Contribution and Collaboration; Data Systems Strengthening and Coordination; and, Emergency Infrastructure and Logistics.

Speakers include:

Dr. Barbara Bentein, UNICEF

Dr. Arnaud Bernaert, World Economic Forum (WEF)

Dr. Vinton G. Cerf, Google

Dr. Denis Gilhooly, Global Digital Health Initiative (GDHI)

Dr. Michael D. McDonald, Global Health Response & Resilience Alliance (GHRRA)

submitted by George Hurlburt

A group of volunteer medical workers carry the bodies of Ebola victims to a car in order to bury them in Kptema graveyard in Kenema, Sierra Leone, on August 24, 2014. Mohammed Elshamy/Anadolu Agency/Getty Images

wired.com - by Erica Check Hayden - June 30, 2015

. . . The patients held the answer. If they survived, they carried antibodies that targeted the very viruses that had almost killed them. The samples he’d been working with didn’t contain antibodies, but if he could get blood from survivors, he might be able to figure out how to make the same antibodies that their immune systems had produced. It would not be easy or fast, but he couldn’t stand by while more people lost their lives—if not in this outbreak, then in the next one, or the next one after that. It was time for a new plan. . . .

. . . Once your body knows how to make antibodies specific to a disease, it never forgets . . . So physicians use survivor serum in the hope that amid the trillions of antibodies an adult human can make, the ones that fight a specific disease will be in the mix. It’s not a new idea.

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