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Exclusive: Guinea says Ebola patients sent home after botched blood tests

REUTERS    by Emma Farge                                                                                      March 2, 2015

 DAKAR - Health officials botched more than 20 Ebola blood tests in January and February which led to the release of at least four positive patients, two of whom later died, Guinea's anti-Ebola coordinator and other health officials told Reuters.

Five health officials and experts familiar with the incidents said the mistakes occurred at two different treatment centers and resulted as many as 52 botched tests, exposing many others to the virus and revealing weaknesses in Guinea's response to the crisis.

Dr Sakoba Keita, Guinea's anti-Ebola coordinator, confirmed the mistake had occurred but gave lower figures. He said in an emailed response to questions that 23 patients were affected, of whom four tested positive when they were retested and two died....

 Health officials, some of whom asked not to be named because they were worried about embarrassing the Guinean government, said the mistakes took place in Coyah, where Cuban medics are supporting a government-run center, and in Conakry, where medical charity Medicins Sans Frontieres runs another center at the Donka hospital complex, when staff placed blood samples in the wrong test tubes, damaging specimens.

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ZMapp Ebola Trial Starts In Liberia: Is It Too Late?

FORBES   by   David Kroll                                                                                          March 1, 2015

The widely-discussed antibody cocktail, ZMapp, is finally going to be tested under standardized, controlled conditions for its safety and efficacy in Ebola virus disease-infected patients in Liberia and, potentially, the United States.

Late Friday, the NIH National Institute of Allergy and Infectious Disease (NIAID) announced the launch of a randomized trial in up to 200 patient volunteers with confirmed Ebola virus infections.

The two-arm study will compare supportive standard of care with or without three intravenous infusions of ZMapp spaced three days apart. This is the same dosing regimen published in Nature that protected 18 of 18 monkeys when given up to five days after experimental infection.

LeafBio, the commercial arm of San Diego-based Mapp Biopharmaceutical, announced concomitantly that the FDA had approved their IND for this trial. The three antibodies that comprise ZMapp target both distinct and overlapping parts of the Ebola virus glycoprotein (GP) that it uses to infect humans.

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The fear of Ebola led to slayings — and a whole village was punished

Detailed account of the aftermath of murder by local villagers in Guinea of eight persons who came to teach about Ebola

WASHINGTON POST  by Amy Brittain                                                                             March 1, 2015
WOMEY, Guinea — The lecture about the dangers of Ebola had just begun, but the village had heard enough. A group of women started chanting, to warn the others against the visitors, “They are coming to kill you.” A mob of men masked their faces, waved machetes and rushed toward the speakers. Stones began to fly.

 

Thousands of Womey residents fled after the killings when Guinea’s military invaded and looted the vllage. More than a dozen died from malnutrition after living for months in the surrounding bushland. (Jane Hahn/For The Washington Post)

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Thoughts turn to recovery as Ebola slowly ebbs in West Africa

 REUTERS By Daniel Flynn, James Harding Giahyue and Saliou Samb                              Feb. 27, 2015

 DAKAR/MONROVIA/CONAKRY - In the marble atrium of the Mammy Yoko hotel in Freetown, manager Nuno Neves has spotted something he has not seen since the Ebola virus struck Sierra Leone nine months ago: foreign businessmen.

The Radisson Blu chain opened the four-star hotel in April to cater for investors in one of Africa's fastest-growing economies. A month later, Ebola crossed the border from Guinea and those investors fled....

For months, Sierra Leone was cut off from the world amid panic at the worst recorded outbreak of the hemorrhagic fever, which has killed more than 9,500 people in Sierra Leone, Guinea and Liberia and infected over 23,500.

But with infection rates slowly declining, investors have begun to talk about post-Ebola reconstruction. Neves has noted the return of businessmen not seen since the hotel opened.

"They don't bring their teams. They just come to see what is going on and then they leave," he said, adding that 'business as usual' remains far off. "This will be a year focused on Ebola. First the fight to end Ebola and then reconstruction...."

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It Kills Germs For Up To 6 Hours. Can It Wipe Out Ebola?

NATIONAL PUBLIC RADIO  by Emily Sohn                                                              Feb. 27, 2015

Clean hands go a long way toward preventing the spread of many illnesses, including Ebola. But finding the right hand-wash to impede deadly germs is tricky.

           A health worker in Liberia washes up after leaving a clinic's Ebola isolation area. Tommy Trenchard for NPR

A squirt of alcohol-based sanitizer like Purell kills or denatures many microbes on contact. In the case of bacteria, essentially poking holes in their cell membranes, causing them to shrivel up like water balloons. For viruses, the mechanism is not well-understood. But alcohol evaporates after 15 seconds, allowing for rapid recontamination...

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Ebola: Sierra Leone village in lockdown after 31 new cases recorded

THE GUARDIAN by Lisa O'Carroll                         Feb. 27, 2015

Efforts to beat Ebola in Sierra Leone have been dealt a setback after 31 new cases were recorded in one village.

                            Red Cross healthcare workers. 

The community of 500 just outside the town of Makeni has now been put in lockdown by the army amid fears that more could be infected.

The World Health Organisation said cases have been linked to one man who escaped a quarantine in Freetown to go home to his village to get treatment from a traditional faith healer.

The quarantine area is a fishing community, yards from the hotel where many of humanitarian agencies have stayed.

Read complete story.
http://www.theguardian.com/world/2015/feb/27/ebola-sierra-leone-village-lockdown-31-new-cases

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Decision on Ebola mass vaccination in August at earliest: WHO

REUTERS by Stephanie Nebehay                                                             Feb. 27, 2015

GENEVA -- An independent advisory body will decide in August at the earliest on whether to recommend widespread introduction of an Ebola vaccine, depending on results of clinical trials and the epidemic's course, the World Health Organization said on Friday.

All three worst-hit countries in West Africa - Guinea, Liberia and Sierra Leone - aim to conduct phase III final-stage clinical trials of experimental vaccines.

Liberia is already testing both the GlaxoSmithKline and Merck-NewLink vaccines, while Sierra Leone and Guinea are due to announce plans soon....

WHO spokesman Christian Lindmeier, reporting on a three-day meeting of experts, told a news briefing: "Vaccine introduction is by no means a given and will depend on the results of clinical trials and recommendations from WHO's Strategy Advisory Group of Experts (SAGE) on vaccines and immunization....

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Fatality Rate Is Falling in West African Ebola Clinics

NEW YORK TIMES  by Donald G. McNeil, Jr.                 Feb. 27, 2015

SEATTLE — As the Ebola epidemic in West Africa wanes, physicians from Doctors Without Borders are confronting a mystery: More of their patients are surviving. They do not know why.

Benetha Coleman, an Ebola survivor and nurse’s aide, comforted a baby with Ebola symptoms in Liberia, as seen through a net. Credit John Moore/Getty Images

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Traditional healer called back to remove curse of first Ebola-affected village in Guinea

ASSOCIATED PRESS By YOUSSOUF BAH                       Feb. 25, 2015
MELIANDOU, Guinea (AP) — Here at ground zero of West Africa's Ebola outbreak, a local traditional healer returned to complete the removal of a curse residents believe could have been placed on their village in Guinea.

In this photo taken on Feb. 23, 2015, traditional healers, right, take part in a exorcism as villagers hand them a chicken, in Meliandou, Guinea. Here at ground zero of West Africa’s Ebola outbreak, a local traditional healer returned to complete the removal of a curse residents believe could have been placed on their village in Guinea. (AP Photo/Youssouf Bah)

It is the same village where experts believe 2-year-old Emile Ouamouno was the first person to have died from Ebola, on Dec. 28, 2013, in the outbreak that has slowed in recent months but has not been completely stamped out....Hundreds abandoned the village, believing the Ouamouno family or the entire village, was cursed, the village chief Amadou Kamano remembered.

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Report Slams U.S. Ebola Response and Readiness

NBC NEWS  by Maggie Fox                                                                               Feb. 26, 2015

The United States fumbled its response to the Ebola epidemic before it even began, neglecting experiments to make vaccines and drugs against the virus, and cutting funding to key public health agencies, a presidential commission said Thursday.

Americans focused on their own almost nonexistent risk of catching Ebola from travelers instead of pressing to help the truly affected nations, the scathing report from the Presidential Commission for the Study of Bioethical Issues says.

They've been acting against their own best interest, the commission said in its report.

"Both justice and prudence demand that we do our part in combating such devastating outbreaks. Once we recognize our humanitarian obligations and the ability of infectious diseases to travel in our interconnected world, we cannot choose between the ethical and the prudential," it reads.

"Ethics and enlightened interest converge in calling for our country to address epidemics at their source."

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