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Ebola Death Rates Vary Widely by Age Group

LIVE SCIENCE       by

Young children who are infected with Ebola may be more likely to die from the virus than older children or adults who are infected, according to a new study.

 In the study, researchers examined Ebola cases in children younger than 16 during the current outbreak in Guinea, Liberia and Sierra Leone, and compared them with adult cases. They found that the outbreak's death rate has been higher among younger children than among older children and adults.

The disease has killed about 90 percent of infected children under age 1, and about 80 percent of kids ages 1 to 4 who have been infected. Older children who have been infected with Ebola may have a much better chance of surviving....

"The very youngest of children — neonates  —appear to have the worst outcomes from Ebola," study co-author Dr. Robert Fowler, an associate professor of critical-care medicine at the University of Toronto, said in a statement. (Neonates, or newborns, are babies younger than 1 month.)

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Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons learned from, the Ebola outbreake

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

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WHO Ebola Situation Report - 25 March 2015

WHO  WEEKLY SITUATION REPORT                                         March 25, 2015

Summary 

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Exposure Concerns Grow in Liberia After Diagnosis of First Ebola Case in Weeks

NEW YORK TIMES  by Sheri Fink                                                            March  25, 2015

Worries have widened in recent days over the number of people in Liberia who may have been exposed to the country’s first Ebola case in more than two weeks, a street vendor who lived in a one-bathroom house shared with 52 others in a Monrovia suburb and who had sold food at a school where more than 1,900 students are enrolled.

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New Ebola trial vaccine 'safe': researchers

AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

 But while it triggered an antibody response in test subjects, further trials must be held to establish whether the drug actually protects against Ebola, they said.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

Read complete story.
http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

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Study announces a durable vaccine for Ebola

MEDICAL EXPRESS                                                                                             March 25, 2015

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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The Ebola detectives

The BBC   by Hans Rosling                                                                    March 23, 2015
Interview with Swedish statistician and global health professor Hans Rosling who spent three months working as an epidemiologist in the Liberian Health Ministry helping to tackle the Ebola crisis.

 

                  Hans Rosling flanked by Maj Morris Hunh (China), to his right, and Gen Gary Volesky(U.S.) to his left

Excerpt from BBC interview:

The curve turned around because enough Ebola treatment units were built. Medecins Sans Frontieres ran the biggest. When that was not enough, Liberian doctors and nurses added the next treatment unit. But the race against time in September to provide treatment and isolation for all patients, when the epidemic curve climbed to 30, 40 and 50 patients per day, was won by the WHO.

 By the end of September, Dr Atai from Uganda opened the so-called Island Clinic which meant beds could be offered to all Ebola patients.The curve was curbed for four reasons:

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Fighting Ebola with a holistic vision of big data

TECH REPUBLIC  by Mary Shaklett                                                                         March 24, 2015

Big data practitioners are learning that the laboratory know-how of computer scientists and statisticians must be matched with a holistic, 360-degree vision of the problem to be solved. TheEbola crisis is a prime example....

If big data is going to help solve health issues like Ebola, it must be incorporated into analytics that consider all of the factors shaping the epidemic. These are three of the ingredients that should be factored into Ebola analytics.

1: There are political barriers that stand in the way of obtaining data from cell phone providers that could assist researchers in determining where the disease will strike next.

2: Even if disease researchers could obtain this data, there is a need to "correct" the data for what it doesn't reveal. For example, if less than 50% of a country's population has access to mobile phones and individuals are constantly moving from village to village, how will researchers be able to verify the quality of the data they're getting unless there are people "on the ground" who can verify or provide corrective factors to the data?

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Mistakes That Fueled Ebola Spread Are Preventing Its Containment One Year Later

REUTERS by Emma Farge                                             March 23, 2015

DAKAR, March 23 -- Lapses that fueled the Ebola outbreak after it was first discovered a year ago are dogging the final stages of the fight against the virus as fatigue and complacency set in, delaying the end of the deadly epidemic.

A man is sprayed with disinfectant after he celebrated the memory of a loved one who died due to the Ebola virus at a newly build grave yard for Ebola virus victims in Monrovia, Liberia, Wednesday, March 11, 2015. Liberians held a church service Wednesday for families who lost members to Ebola to mark the country’s 99th celebration National Decoration Day, a holiday normally set aside for people to clean up and re-decorate the graves of their lost relatives. (AP Photo/Abbas Dulleh) | ASSOCIATED PRESS

Three doctors were discovered to be infected with Ebola at a hospital in Guinea's capital Conakry last week in what health reports and government officials blamed on a failure to implement basic measures for infection control.

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