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Ebola raises profile of blood-based therapy

NATURE     by  Delcan Butler                                                                                        Dec. 23, 2014

With no drugs available to treat Ebola, eyes are turning to a therapy that had largely been relegated to the history books: transfusing patients with blood plasma donated by survivors, which contains antibodies against the virus.

Survivors of Ebola carry antibodies that might be used to save the lives of those infected with the virus. Michel du Cille/The Washington Post via Getty Images

Clinical trials of convalescent plasma therapy (CPT) have started in the past few weeks in Liberia, and are due to begin soon in Guinea and Sierra Leone. If the therapy saves lives, the approach could quickly be scaled up.

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C.D.C. Head Says Fight on Ebola Will Be Long

NEW YORK TIMES by Denise Grady                             Dec. 23, 2014
There are reasons for both hope and continued worry about the Ebola epidemic in West Africa, Dr. Thomas R. Frieden, director of the Centers for Disease Control and Prevention, said on Monday.

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Ebola vaccine 'promising in African populations'

BBC     By Smitha Mundasad                                Dec. 22, 2014
The first-ever trial of an Ebola vaccine in Africa shows promising initial results, according to a report in the Lancet medical journal.

Scientists say it is a crucial step as other vaccines have shown lower levels of protection in African populations.

Tests involving Ugandan and American volunteers reveal the vaccine is so far safe and generates an immune response in both populations.

It provides reassurance for other trials currently underway, they say.

No proven vaccine exists to prevent people from getting the disease, though several trials are underway.

Researchers from the National Institutes of Health tested this experimental vaccine on healthy adults in Uganda, having first trialled it in the United States.

Dr Julie Ledgerwood, the lead researcher, said: "This is the first study to show comparable safety and immune response of an experimental Ebola vaccine in an African population.

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http://www.bbc.com/news/health-30577776

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Untested Ebola drug given to patients in Sierra Leone causes UK walkout

THE GUARDIAN           by Sarah Boseley                                                                    Dec. 22, 2014

FREETOWN, Sierra Leone -- Ebola patients at a treatment centre in Sierra Leone have been given a heart drug that is untested against the virus in animals and humans, a move that has been deemed reckless by one senior scientist and has prompted UK medical staff at the centre to leave.

                British health workers help an Ebola patient in Freetown, Sierra Leone. Photograph: Baz Ratner/Reuters

A 14-strong team of British doctors, nurses and paramedics stopped working at the Lakka treatment centre in Freetown because of their concerns over what they considered the experimental and potentially dangerous use of the drug, and other safety issues.

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Can the blood of Ebola survivors create a cure?

REUTERS       by  Julie Steenhuysen                                                                                 Dec. 22, 2014
CHICAGO --For months, Vanderbilt University researcher Dr. James Crowe has been desperately seeking access to the blood of U.S. Ebola survivors, hoping to extract the proteins that helped them overcome the deadly virus for use in new, potent drugs.

Blood samples from patients suspected of having the Ebola virus disease are prepared for transportation to Freetown for testing, at the Port Loko District Hospital September 27, 2014. Credit: Reuters/Christopher Black/WHO/Handout via Reuters

His efforts finally paid off in mid-November with a donation from Dr. Rick Sacra, a University of Massachusetts physician who contracted Ebola while working in Liberia. The donation puts Crowe at the forefront of a new model for fighting the virus...

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IMF policies blamed for Ebola spread in West Africa

BBC                                                                                                                       Dec. 22 2014

Spending cuts imposed by the International Monetary Fund (IMF) may have contributed to the rapid spread of Ebola in three West African states, UK-based researchers say.

                      Sierra Leone, along with Liberia and Guinea, have poor health facilities

It had led to "under-funded, insufficiently staffed, and poorly prepared health systems" in Sierra Leone, Liberia and Guinea, they said.

The IMF denied the allegation.

"A major reason why the Ebola outbreak spread so rapidly was the weakness of healthcare systems in the region, and it would be unfortunate if underlying causes were overlooked," said Cambridge University sociologist and lead study author Alexander Kentikelenis....

The IMF said in a statement that health spending in Guinea, Liberia and Sierra Leone had, in fact, increased in the 2010-2013 period.

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Ebola response in rural Sierra Leone not yet rapid enough

REUTERS   by    Emma Farge                                                                                                 Dec. 21, 2014       
KOIDU, Sierra Leone -- The rapid response team has arrived and the chaos is easing, but medics in a remote Sierra Leonean district are struggling to control a local Ebola outbreak when it's too late to nip it in the bud.

Health workers rest outside a quarantine zone at a Red Cross facility in the town of Koidu, Kono district in Eastern Sierra Leone December 19, 2014. Credit: Reuters/Baz Ratner

A deployment of medical workers and equipment to Kono District has been the fastest so far in Sierra Leone, a country with nearly half the total Ebola cases,- under a strategy of tackling epidemic hotspots before they get too big.

But officials say responses need to be yet faster to fight the fever that has killed more than 7,000 people across West Africa.

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Sierra Leone Urges Safe Burials to Stem Ebola

ASSOCIATED PRESS  by SARAH DiLORENZO                       Dec. 21, 2014
DAKAR, Senegal --The radio announcement is chilling and blunt: "If I die, I want the deaths to stop with me."

Dr. Desmond Williams continues: "I want to give my family the permission to request a safe and dignified, medical burial for me."

The announcement is part of a campaign to urge Sierra Leoneans to abandon traditional burial practices, such as relatives touching or washing the dead bodies, that are fueling the spread of Ebola in the West African country.

 Officials are resorting to increasingly desperate measures to clamp down on traditional burials in Sierra Leone, where Ebola is now spreading fastest. The head of the Ebola response has even threatened to jail people who prepare the corpses of their loved ones.

Williams, a Sierra Leonean-American doctor who works for the U.S. Centers for Disease Control and Prevention, took to the airwaves last month as part of efforts to encourage people to avoid dangerous burial practices. Now similar pledges have been made by prominent Sierra Leoneans, including the communications director for the Health Ministry, pop stars and radio DJ's.

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Ebola Should Be Easy to Treat

NEW YORK TIMES SUNDAY REVIEW   by Jeffrey Gettleman                                            Dec. 21, 2014

FREETOWN, Sierra Leone --
...Ebola, however much some of its symptoms conjure up a horror film, is usually shockingly simple to treat. The virus is swift and ruthless, hideous and creepy, causing some patients to have bloody vomit, bloody diarrhea or even — in severe cases — bloody eyeballs. Ebola is one of the handful of viruses than can trigger a hemorrhagic fever, with internal bleeding, but in most cases the biggest threat is dehydration, which can be addressed by clean water and basic drugs.

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S Leone to withdraw Somalia troops over Ebola

African Union blocks troops rotation over Ebola fears, forcing Sierra Leone to withdraw its 850 soldiers from Somalia.

ALJAZERA     by     Hansa Mohamed                             Dec. 21, 2014

Sierra Leone is withdrawing its troops from Somalia after the African Union blocked the West African country from rotating its soldiers over fears for the Ebola virus.

Sierra Leone sent 850 troops to Somalia for a 12-month deployment to fight the al-Qaeda-linked rebel group, al-Shabab, in Somalia in 2013.

Their rotation was delayed after a group of 800 soldiers, who were waiting to replace their comrades in Somalia, were quarantined after one of the soldiers was tested positive for Ebola.

"They have to go. We wish they could have stayed but they have been here long. And there is no rotation possible because of the nature of the situation," Maman Sidou, the AU's special representative for Somalia said during a farewell event for the troops held in the port city of Kismayo on Friday.

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